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A 30-year-old man came to the outpatient department because he had suddenly developed double vision. On examination it was found that his right eye, when at rest, was turned medially. The most likely anatomical structures involved are: A. Medial rectus and superior division of oculmotor nerve. B. Inferior oblique and inferior division of oculomotor nerve. C. Lateral rectus and abducent nerve. D. Superior rectus and trochlear nerve. Answer: C (Lateral rectus and abducent nerve) Ref: All Anatomy, Most Physiology, All Medicine, All Paediatric, All Ophthalmology, few Surgery books Quality: First MBBS Status: Abused QTDF: First MBBS MCQ Question Papers!!!J Discussion He developed double vision. Right eye turned medially. So there is lateral rectus palsy. So lateral rectus is involved. And the nerve supply of lateral rectus is ??? Explanation Self explanatory. Please refer yourself with the nerve supply of extraocular muscles. Constraints of space in this small book prevent me from giving these well known facts. Comments No comments. Tips Just because you see few questions like this dont get a wrong impression about the standard of the question paper and as I have already told you, whenever you get a question that seems so simple, read it once more. (Though not here) There might be a Trap. 22. Which of the following is true about the autonomic nervous system? A. The sympathetic outflow from the CNS is through both the cranial nerves and the sympathetic chain. B. The parasympathetic outflow from the CNS is through the cranial nerves only. C. The superior hypogastric plexus is located at the anterior aspect of the aortic bifurcation and fifth lumbar vertebra. D. The superior hypogastric plexus contains sympathetic fibres only. 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Punctate bleeding spots on cut Quality: Ref: Discussion Explanation correct choice VZGdZGdZGdZGdZGd"ZGdZGdZGdZGdZGdZGdZGdZGdZGdZGdZGdZGdVh<(xKddd (xKdd (xKdd (xKdd (xKdd# (xKdd (xKdd (xKdd ,(xKdd ,(xKdd (xKdd (xKdd (xKdd (xKddVh,@ l ,@ l ,@ l ,@ l #,@ l ,@ l ,@ l ,@ l ,@ l ,@ l ,@ l ,@ l ,@ l :#A#C^cc,m Ccc,m Ccc,m CNcc,m Ccc,m CPcc,mC&cC,ca67#hXCh@B<ca:"CX caN-CX! caD8+Xh CXca01CX@B,3#C@B#C @Bc)C@ CC@@, C=#C|ca:CXRcaNCXcaDCXo CgcC,camChcam(Ch cam8+hX5#hX4Chc6#,Cacam9+hXCh^cam5#hX1Ch Cc#C, cam;#hX;#hX3Chcam9+hX!Ch cam:#hX6#hXCh/cam;#hX Chc:#,<#A#9#8#>##C] camChcam8+hX0Chcam6Chcam5#hX8#hXChE@B, Cca:CXcaNCXxcaD1+Xh0#Xh CXca0CX@B, Cz?#-C@@,Cr;#:#8#?#,CCrca6:#hX5Ch@@B<ca: CXcaN CXcaD CXca0CX@@,,C&@B:#A#(C @Bc\$CHx C:C@B, C3#.CNca:CXcaN4#XhCXcaD3#XhCX%ca02#Xh6CXcpink3  ,/ .HP LaserJet 2100 Series PCL 6HP LaserJet 2100 Series PCL 6LPT1:@@xGMMd(xKdddContents^tIndex ,^>;^>^=.^>X C:\PM6\RSRC\USENGLSHxA88dd0PP  db ..--__  a64#hX4#hX5#hX6#hXCh@B<ca:1#XhCXcaN5#XhCXcaD#CX ca0%CX2 @@,.C(@BA#&Cc @@c{C@ C*C@B, C:#B#*C @B, C>#@#/C|@B, CzC@@,Cr@#;#:#<#CfCCtca63#hXChL@@<ca:5#Xh.CX caN4#XhCX?caD5+Xh;#Xh CXca08#Xh CX~@@,=#># C@B,;# Cc C@ C C @B, C?#;#>#@#A#:#7# C@B, Cca:4#Xh4#XhCX<caN4#Xh8#Xh0CX[caD5+Xh;#Xh7#XhCX\ca08#Xh6#XhCX @@, Cz?#@#;#<#0#:#=#BC@@,Cr/CCCca66#hX$Ch @B<ca:CXJcaN CXcaDCXca0 CXC4@B"C @@8CC+C@B, CC@ ca chJcT.C ca chcT.&# CFcachcT.-# CDca chcT.+# CcachcT.%C @B, Cca:CXcaNCXcaDCXca0:+XhCX3@@, Cz4C@@,Cr;#9#*C cC,Ctca69#hXCh6@B<ca:CXBcaNCXcaDCXca0CX~@@,C @B@#C@@Cc]C@ C C @B, C:#1#=#?#?#9#<#=#<#=#>#;#/CiCdCch chPchtch  ChCdCch chPchch JChich chP?ch ch #hchchPch=ch chn#hchchPchch chGdZGd<ZGdZGdZGdZGdZGdZGdZGdZGdZGdZGdZGd(ZGdZGd9ZGdZGdZGdZGdZGdZGd ZGdZGdZGdZGd&ZGdZGdZGdZGd*ZGdZGd5ZGdZGd ZGdZGdZGdZGd!ZGdZGdZGdZGdZGdZGdZGdZGd ZGdZGd&ZGdZGd%ZGdtations presenilin,apo*,@ l #XXXX,@ l ,@ l ,@ l ,@ l 7,@ l ,@ l !,@ l ,@ l ,@ l $,@ l -,@ l ,@ l $,@ l ),@ l 1,@ l ,@ l g,@ l H,@ l ,@ l ,@ l C,@ l ,@ l H,@ l M,@ l ,@ l ,@ l issociation of COHb. Hyperbaric O2 is useful. 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The questions are distributed as follows. Arteries : 2 Veins : 3 Nerves : 6 Bone : 3 Muscle : 1 Histology : 1 12. The most common variation in the arteries arising from the arch of aorta is: A. Absence of brachiocephalic trunk. B. Left vertebral artery arising from the arch. C. Left common carotid artery arising from brachiocephalic trunk. D. Presence of retro-oesophageal subclavian artery. Answer: C (Left common carotid artery arising from brachiocephalic trunk) Ref: Grays Anatomy 38th edn, 1513 Quality: Spotter Status: High Yield Topic QTDF: Gray's Anatomy Discussion Normally the following branches of arch of aorta spring from the vessels convex aspect: A. The brachiocephalic trunk, B. Left common carotid and C. Left subclavian arteries. Variations: They may branch from: The beginning of the arch or The upper part of the ascending aorta; The distance between these origins varies, the most frequent being approximation of the left common carotid artery to the brachiocephalic trunk (Wright 1969). Primary branches may be reduced to one, more commonly two: the left common carotid arising from the brachiocephalic trunk (7%), or (more rarely) the left common carotid and subclavian arteries arising from a left brachiocephalic or Primary branches may be increased: Right common carotid and subclavian arising separately, in which case the latter more often branches from the left end of the arch and passes behind the oesophagus. The left vertebral artery may arise between the left common carotid and the subclavian. Very rarely, external and internal carotid arteries arise separately, the common carotid being absent on one or both sides; or Both carotids and one or both vertebrals may be separate branches. When a right aorta occurs, the arrangement of its three branches is reversed. The common carotids may have a single trunk, the subclavians separate, the right arising from the left end of the arch. Other arteries may branch from it, most commonly one or both bronchial arteries and the arteria thyroidea ima. An analysis of variation in branches from 1000 aortic arches (Anson 1963) showed: in 65% the usual pattern; in 27% a left common carotid shared the brachiocephalic trunk (contrast percentage quoted above); in 2.5% the four large arteries branched separately; The remaining 5% showed a great variety of patterns, the most common (1.2%) being symmetrical right and left brachiocephalic trunks. Explanation A. Rare. B. This is a rare chance. C. This has 7% incidence in one study and 27% in another study and undoubtedly is the most common variation. D. This is a rare occurrence. Comments This is a question directly from Gray's Anatomy and only those who have read it can answer with confidence. Tips Arteries and branches is a high yield topic in anatomy. Go through the high yield topics. Other high yield topics in anatomy would include veins and tributaries, nerves and branches, sensory supply of a nerve, origin, insertion, action and nerve supply of muscles and dermatomes. 13. The right coronary artery supplies all of the following parts of the conducting system in the heart, except: A. SA node. B. AV node. C. AV bundle. D. Right bundle branch. Answer: A (SA node) D (Right bundle branch) Ref: Grays Anatomy 38th edn, 1510; Fundamentals ofHuman Anatomy (Regional and Applied) Dr.A.S.Moni - Vol II, 37; Snells Clinical Anatomy 6th edn, 105; BDC, 226 Quality: Confusa !!! 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When you get questions like this, try to find what book could have been used. For this, scan the other questions from the same subject and the nearby questions and try to find whether you can pick any QTDF in the nearby questions and then go for the answer that book gives. If not, we can safely leave the question (Easier said than done!!). 20. Referred pain from ureteric colic is felt in the groin due to involvement of the following nerve: A. Subcostal. B. Iliohypogastric. C. Ilioinguinal. D. Genitofemoral Answer: D (Genitofemoral) Ref: Gray's Anatomy 38th edn, Abdominal urinary Organsureters, 1833 Quality: Spotter Status: High Yield TopicNerve Supply QTDF: Gray Discussion Clinical Anatomy: As in the case of the gut, excessive ureteric distension or spasm of its muscle provokes severe pain (renal colic), for example, by a stone (calculus) causing incomplete and intermittent obstruction, particularly if it is gradually forced down by the muscle spasm. The pain, spasmodic and agonizing, is referred to cutaneous areas innervated from spinal segments which supply the ureter, mainly T11L2. It shoots down and forwards from the loin to the groin and scrotum or labium majus and may extend into the proximal anterior aspect of the thigh by projection to the genitofemoral nerve (L1, 2); the cremaster (which has the same innervation) may reflexly retract the testis. Explanation A. Subcostal is not our nerve. B. Iliohypogastric also is not the answer. C. This is a confusa. D. Genitofemoral nerve is the answer as per Gray's Anatomy. Comments There were (and are) few who say that the answer is ilioinguinal, but in my opinion, when Grays Anatomy says a point we have to accept it without arguing. Remember that Gray enjoys a position unparalleled in the enire (never ending) list of books used by a doctor. For no other subject we have a book that is accepted as the Gold Standard in all parts of world. (As far as India is concerned, PARK is the Emperor). Tips A ureteric stone is liable to impact at one of the ureteric constrictions, namely (1) its superior end, (2) where it crosses the brim of lesser pelvis or (3) as it passes through the vesical wall; radiologically, it would appear near the tip of the second lumbar transverse process, overlying the sacro-iliac joint, or slightly medial to the ischial spine. Sometimes the ureter is duplicated on one or both sides even as far as the bladder; separate vesical openings are rare in such cases. clinically evident, and C. 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A 30-year-old man came to the outpatient department because he had suddenly developed double vision. On examination it was found that his right eye, when at rest, was turned medially. The most likely anatomical structures involved are: A. Medial rectus and superior division of oculmotor nerve. B. Inferior oblique and inferior division of oculomotor nerve. C. Lateral rectus and abducent nerve. D. Superior rectus and trochlear nerve. Answer: C (Lateral rectus and abducent nerve) Ref: All Anatomy, Most Physiology, All Medicine, All Paediatric, All Ophthalmology, few Surgery books Quality: First MBBS Status: Abused QTDF: First MBBS MCQ Question Papers!!!J Discussion He developed double vision. Right eye turned medially. So there is lateral rectus palsy. So lateral rectus is involved. And the nerve supply of lateral rectus is ??? Explanation Self explanatory. Please refer yourself. Comments No comments with the nerve supply of extra ocular muscles. Constraints of space in this small book prevent me from giving these well known facts. Tips JJust because you see few questions like this dont get a wrong impression about the standard of the question paper and as I have already told you, whenever you get a question that seems so simple, read it once more. (Though not here) There might be a Trap.L 22. Which of the following is true about the autonomic nervous system? A. The sympathetic outflow from the CNS is through both the cranial nerves and the sympathetic chain. B. The parasympathetic outflow from the CNS is through the cranial nerves only. C. The superior hypogastric plexus is located at the anterior aspect of the aortic bifurcation and fifth lumbar vertebra. D. The superior hypogastric plexus contains sympathetic fibres only. Answer: C (The superior hypogastric plexus is located at the anterior aspect of the aortic bifurcation and fifth lumbar vertebra) Ref: Grays Anatomy 38th edn, 1308; BDC 3rd edn, Volume II Page 282 Quality: Reader Status: New QTDF: ,@ l ,@ l ,@ l ,@ l ,@ l ,@ l ,@ l ,@ l Rh&X1XHX5X,@ l G,@ l ,@ l ,@ l ,@ l ,@ l ,@ l ,@ l ,@ l ,@ l ,@ l Z,@ l XXX ,@ l ,cC,This is the trumpeters muscle C. This is the blowing muscle and D. This is the sucking muscle (May look mutually exclusive, but this is the fact). Tips Read the relevant embryology and the nerve supply of these muscles. 27. The cells belonging to the following type of epithelium are provided with extra reserve of cell membrane: A. Transitional. B. Stratified squamous. C. Stratified cuboidal. D. Stratified columnar. Answer: A (Transitional) Ref: Robbins Pathology 6th edn. Chapter 22 Page 997 Quality: Spotter Status: Reader QTDF: Gray, Robbins Discussion Urothelium lines much of the urinary tract, extending from the ends of the collecting ducts of the kidneys, through ureters and bladder to the proximal portion of the urethra. In males, it covers the urethra as far as the ejaculatory ducts, then becomes intermittent, finally being replaced by pseudostratified epithelium in the membranous urethra. In females, it also extends as far as the urogenital membrane. During development, part of it is derived from mesoderm and part from ectoderm and endoderm. The epithelium appears to be 46 cells thick and lines organs which undergo considerable distension and contraction; it can, therefore, stretch greatly without losing its integrity. In stretching, the cells become flattened, without altering their positions relative to each other, since they are firmly connected by numerous desmosomes. On close inspection, many cells are seen to be attached to the basal lamina of the epithelium by slender basal processes and it has been proposed that perhaps all cells, even the most superficial, are attached to the base; thus, this tissue could be viewed as a type of specialised pseudostratified epithelium, in which case, it should be reclassified as a unilaminar epithelium. The basally placed cells are cuboidal when relaxed, uninucleate (diploid) and basophilic with many ribosomes. More apically, the cells progressively fuse to form larger, binucleate or uninucleate but polyploid cells. The surface cells are largest and may even be octoploid; their luminal surfaces are covered by a plasma membrane bearing plates of glycoprotein particles embedded in its lipid bilayer. These arrays stiffen the membrane, so that when the epithelium is in the relaxed state and the surface area of the cells is reduced, the glycoprotein-lipid plates are partially taken into the cytoplasm within vacuoles or diverticula, re-emerging on to the surface when its area increases once more through stretching. These unusual membranes, together with the occluding junctions of the surface cells, form an effective barrier preventing urine from passing into the epithelium or beyond into the adjacent tissues. The urothelium, therefore, creates a protective lining to the urinary system which prevents its rather toxic contents from damaging surrounding structures. Normally, cell turnover is very slow, cell division being restricted to the basal layer, and infrequent. When damaged, however, the epithelium regenerates quite rapidly. Explanation A. Transitional epithelium has an additional reserve of membrane. B. Stratified squamous epithelia are multilayered tissues in which there is a constant formation, maturation and loss of cells. Formed mitotically in the most basal layers, their cells move more superficially, changing from a cuboidal or columnar shape to a more flattened form, and eventually being shed from the surface. These epithelia occur in sites exposed to mechanical stresses and provide for a constant protection of the underlying tissues against mechanical, microbial and chemical damage. C. Stratified cuboidal: Two or more layers of cuboidal cells are typical of the walls of the larger ducts of some exocrine glands, such as the pancreas and salivary glands and the ducts of sweat glands, presumably affording more strength than a single layer. These are not continually replaced by basal mitoses and there is no progression of form from base to surface, although they can repair themselves if damaged. D. Stratified columnar: Two or more layers of columnar cells are typical of the walls of the larger ducts of some exocrine glands, such as the pancreas and salivary glands and the ducts of sweat glands, presumably affording more strength than a single layer. These are not continually replaced by basal mitoses and there is no progression of form from base to surface, although they can repair themselves if damaged. Comments There is one more transitional epithelium !!!! In the semicircular canals, where they border areas of sensory epithelium, the epithelial cells show a marked contrast with the unspecialised ductal cells, and here the underlying connective tissue layer is also thicker. 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C:#1#=#?#?#9#<#=#<#=#>#;#/CiCdCch chPchtch  ChCdCch chPchch JChich chP?ch ch #hchchPch=ch chn#hchchPchch chYE hG_{,@ l h ,@ l AXXXdX ,@ l ,@ l ,@ l ,@ l X(xKddd ,(xKdd( ,(xKdd (xKdd (xKdd (xKdd (xKdd (xKdd (xKdd (xKdd (xKdd ,(xKdd (xKdd (xKdd (xKdd (xKdd (xKdd ,(xKddWX(xKdddjX(xKddd?X(xKddd>X(xKddd ,(xKdd5 (xKdd ,(xKddg (xKdd<h<(xKdddX(xKddd X(xKdddX(xKdddX(xKddd (xKdd (xKdd (xKdd (xKdd (xKdd (xKdd (xKdd (xKdd (xKdd (xKdd (xKdd ,(xKdd (xKdd ,(xKdd!X(xKdddX(xKddd'X(xKdddX(xKddd (xKdd (xKdd (xKddi (xKddh ,@ l 7,@ l ,@ l >,@ l ,@ l _h)X7X XX,@ l ,@ l ,@ l ,@ l ,@ l ,4@ l ,4@ l ,4@ l 5,4@ l ,@ l ,@ l ,@ l ,@ l Fundamentals of Human Anatomy by Dr.Moni gives the branches of right coronary artery as follows: A. Branch to SA node B. Marginal artery supplies the anterior and posterior surfaces of right ventricle C. AV nodal artery supplies the AV node and its right branch D. Post IV branchsupplies the post 1/3 of IV septum and the posterior surface of right and left ventricle E. Branches to right atrium F. Vasavasorum to the ascending aorta The same views are shared by BDC who says that RCA supplies the whole of conducting system of heart except left bundle. Then the answer will be 1.SA node, which has dual supply. But Snell says that the conducting system is supplied like this: SA node supplied by RCA, LCA AV node supplied by RCA, Bundle supplied by RCA Right branch supplied by LCA Left branch supplied by RCA LCA So according to Snell, the answer is 4.Right bundle branch. Explanation A. SA node is supplied by the branch to SA node. And it has dual supply. B. AV node is supplied by the AV nodal artery from RCA. C. AV bundle is supplied by the right coronary artery (BDC) as well as by LCA (Snell). D. Right bundle branch is supplied by the AV nodal artery. Comments Anatomy of the heart is a high yield topic. Arteries and veins are another high yield topic and there is no wonder that we got a theme couple for this topic in AIPG 2003. Tips Read the blood supply of areas of brain, especially the internal capsule. 14. Middle cardiac vein is located at the: A. Anterior interventricular sulcus. B. Posterior interventricular sulcus. C. Posterior AV groove. D. Anterior AV groove. Answer: B (Posterior interventricular sulcus) Ref: Grays Anatomy 38th edn, 1576 Quality: Spotter Status: Repeat QTDF: Gray Discussion Location Artery Vein Coronary sulcus Right coronary artery Coronary sinus and left coronary artery Anterior part of Right coronary artery Small cardiac vein coronary sulcus and Anterior inter Anterior interventri- Great cardiac vein -ventricular groove cular artery Posterior interven- Posterior interven- Middle cardiac vein tricular groove tricular artery Left atrioventricular Circumflex artery Great cardiac vein and groove coronary sinus Interatrial groove Oblique vein of Marshal Explanation A. Anterior interventricular sulcus has right coronary artery and small cardiac vein. B. Posterior interventricular sulcus has posterior interventricular artery and middle cardiac vein. C. Posterior AV groove is not related to middle cardiac vein. D. Anterior AV groove is not related to middle cardiac vein. Comments As always anatomy of heart is a high yielding topic. Tips Oblique vein of Marshal drains left atrium and is the only tributary of coronary sinus without valves. 15. The blood vessel related to the paraduodenal fossa is: A. Gonadal Vein. B. Superior mesenteric artery. C. Portal vein. D. Inferior mesenteric vein. Answer: D (Inferior mesenteric vein) Ref: Grays Anatomy 38th edn, 1603; BDC 3rd edn II Volume, 204 Quality: Spotter Status: New from High Yield Topic QTDF: Gray's Anatomy Discussion Inferior mesenteric vein drains the rectum, and sigmoid and descending parts of the colon. It begins as the superior rectal vein, from the rectal plexus, through which it connects with middle and inferior rectal veins. The superior rectal vein leaves the pelvis and crosses the left common iliac vessels medial to the left ureter with the superior rectal artery, continuing up as the inferior mesenteric vein. This is left of its artery, ascending behind the peritoneum anterior to the left psoas major; it may cross the testicular or ovarian vessels or be medial to them and then passes above, or behind, the duodenojejunal flexure, opening into the splenic vein posterior to the body of the pancreas; sometimes, it ends at the union of the splenic and superior mesenteric veins. If a duodenal or paraduodenal fossa exists, the vein is usually in its anterior wall. Its tributaries are sigmoid veins from the sigmoid colon and the left colic vein from the descending colon and the left colic flexure. Explanation A. Gonadal vein is not related. B. This does not come here. C. Portal vein also is not related. D. As seen above, inferior mesenteric vein along with the ascending branch left colic artery are seen in the free edge of paraduodenal fold. Comments A question directly from Gray's Tips Go through the various fossae, recesses and the triangles. 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The pronator quadratus is also involved but is not clinically significant. Carpal Tunnel Syndrome This is the most common entrapment mononeuropathy caused by the compression of the median nerve as it passes through the fibro-osseous tunnel beneath the flexor retinaculum. Causes The carpal tunnel may be narrowed by: A. Arthritic changes in the wrist joint, particularly rheumatoid arthritis; B. Soft tissue thickening as may occur in myxoedema and acromegaly; C. Oedema and obesity including pregnancy. Pathology Normally, the nerve slides smoothly in and out of the carpal tunnel with flexion and extension of the wrist; when the nerve is compressed, there is an additional damage to the nerve with flexion and extension. The dominant hand is usually affected first, probably because this hand is used more frequently and more vigorously. Motor There is wasting and weakness of abductor pollicis brevis: Sensory Impairment of sensation in the: A. Thumb, B. Index finger, C. Middle finger and D. Median side of the ring finger, (xKd",T <?,@ l ,@ l KX9XXX=X ,@ l ,@ l ,@ l J,@ l ,h&X'XXX,@ l (,@ l ,@ l ,@ l ,@ l ,@ l ,@ l ,@ l ,@ l @ Cv9#9#X(xKddd;(xKddd/ (xKdd (xKddh(xKdddT(xKddd(xKddd(h(xKdddY(xKdddE(xKddd h(xKdddG(xKddd_(xKddd (xKdd ,(xKddhxP(xKddd(xKddd&hxP(xKddd(xKddd^hxP(xKddd(xKddd?hxP(xKdddP(xKdddhxP(xKddd(xKddd ,(xKddAX(xKdddX(xKdddX(xKdddbX(xKddd ,(xKdd (xKdd (xKdd ,(xKdd (xKdd (xKdd, (xKdd+X(xKddd,X(xKddd ,(xKdd@ (xKdd ,(xKdd2 (xKddaX(xKddd@X(xKdddSX(xKddd ,(xKdd (xKdd (xKdd (xKddL (xKdd (xKdd# ,(xKdd (xKdd ,(xKdd@X(xKdddTX(xKdddlX(xKddd (xKdd (xKdd (xKdd (xKdd ,(xKdd (xKdd ,(xKdd' (xKddPX(xKdddFX(xKddd-X(xKddd ,(xKdd (xKddw (xKdd x(xKdd< (xKdd x(xKdd! (xKdd X(xKdddX(xKdddX(xKddd%X(xKdddcX(xKddd ,(xKddaculum. Causes The carpal tunnel may be narrowed by: A. Arthritic changes in the wrist joint, particularly rheumatoid arthritis; B. Soft tissue thickening as may occur in myxoedema and acromegaly; C. Oedema and obesity including pregnancy. Pathology Normally, the nerve slides smoothly in and out of the carpal tunnel with flexion and extension of the wrist; when the nerve is compressed, there is an additional damage to the nerve with flexion and extension. The dominant hand is usually affected first, probably because this hand is used more frequently and more vigorously. Motor There is wasting and weakness of abductor pollicis brevis: Sensory Impairment of sensation in the: A. Thumb, B. Index finger, C. Middle finger and D. Median side of the ring finger, ( the resting membrane potential depends on which of the following ions A. Magnesium B. Calcium C. Potassium D. Sodium 5. Chloride Ref:: Ganong 50 Quality: spotter Discussion The ionic basis of RMP: Explanation A. Magnesium has no role in RMP. B. Calcium has role in action potential in muscle cells not RMP C. Potassium. The major ion whose movements produce RMP. Correct choice. D. Sodium. incorrect choice. 5. Chloride. No role. Correct choices C 79. In acute inflammation the migration of neutrophils and its attachment to endothelium is mediated by which of the follwing. a. Integrins b. Selection s c. Adhesins d. Perforins e. Opsonins Ref:: Robbins 29, 273 Quality:spotter thinker reader BATA Explanation a. Integrins are transmembrane glycoproteins that function as cell receptors for extra cellular matrix. correct choice. b. Selectins=the loose and transient adhesions involved in rolling of leucocytes over endothelial cells are accounted for by the selectin family of molecules. E-selectin are present on on endothelial cells, P-selectin on platelets and endothelial cells and L-Selectins on leucocytes. c. Adhesins-are molecules that bind bacteria to cells e. g. lipoteichoic acid and protein F. d. Two classes of cytotoxins include perforins and granzymes. . The perforins form pores in the targets cell membranes. incorrect choice. e. Opsonins are protiens or peptides that label targets for phagocytosis by PMNs and/or macrophages. incorrect choice, Correct choices b 102. Susruta samhita was translated by a. Celsius b. harnel c. Bhargabhatta d. heslar e. Bernard Ref: http://www. ayurveda. com/online%20resource/ancient_writings. htm Quality: BATA Discussion: http://www. ayurveda. com/online%20resource/ancient_writings. htm Sushruta Samhita The Sushruta Samhita deals with the practice and theory of surgery, is an important source of Ayurvedic aphorisms. This work is the first to enumerate and discuss the pitta sub-doshas and the marmas. With its emphasis on pitta, surgery, and blood, this work best represents the transformational value of life. It is dais that this work was first redacted by Nagarjuna. This work, originally written in Sanskrit, is now available in English with Devanagari. Bhishagratnas translation is English and Sanskrit. P. V. Sharma has recently written a translation with both the Sanskrit/Devanagari and English that includes Dallanas commentary. Dallana has been regarded as the most influential commentator on Sushrutas work. Explanation Correct choices B d 21. Prozone phenomenon in precipitation reaction indicates a. False positive reaction b. False negative reaction c. due to excess antibodies d. Due to excess antigens e. Broken antibodies Ref: : AN 91 Quality: spotter 203. Which of the following are features of spinal shock f. Spasticity g. urinary retention h. Areflexia i. Sensory level j. Increased DTRs Ref::clinical acumen Quality:spotter thinker reader BATA Discussion Spinal shock(neuronal) is the initial state just after an acute insult causing an uMN lesion caused by the temporary depressant effect on the anterior horn cells. Characterized by paralysis,areflexia,flaccidity,the chracteristic hypertonia and increased relexes of cotticospinal lesion appear after few hrs-days. Explanation 6. Spasticity appears hrs day after spinal shock has passed in an uMN lesion. 7. urinary retention is a feature of spinal cord disease. appears first in case of disease originating from the canal and spreading outwards and last in mass lesions compressing spinal cord from the outside. Its a feature of spinal shock. 8. Areflexia is a feature of spinal shock. 9. Sensory level is seen in case of corticospinal lesion. 10. Increased DTRs will be seen after the spinal shock has passed. Correct choices B C d 202. Diseases inherited with triple repeat sequences include a. Huntingtons chorea b. Alzheimers disease c. Spinocerebellar ataxia d. Amyotrophic lateral sclerosis e. Ataxia telangiectasia Ref:: Robbins 197,739,741,157 Quality:spotter thinker reader BATA Discussion Harrison 2294 table gives explicit information about genetic defects in neurological disease. Robbins has enumerated three diseases having triple repeat sequences: Fragile X syndrome Huntington;s ds, Myotonic dystrophy Explanation A. Huntingtons chorea:AD : CAG triple repeats in gene encoding proein huntingtin B. Alzheimers disease:AD mutations presenilin,apolipoprotein E4,APP genen C. Spinocerebellar ataxia:expansion of trinucleotide repeats in ataxin gene D. Amyotrophic lateral sclerosis:AD mutation in Cu-Zn superoxide Dismutase SOD. 5. Ataxia telangiectasia AR mutation in ATM gene which causes triple repeat sequences and abnormal production of protein. Correct choices A c e 59. Tumor markers of hepatocellular carcinoma include a. CEA b. Des gamma carboxyprothrombin c. CA 19-9 d. Fucosylated alpha protein e. Alpha fetoprotien elevated in greater than 70% Ref:: HPIM 579, CMDT 689 Leaves extension at elbow joint intact) Ref: Snells 6th, 493Arial" !Bookshelf Symbol 3!Helvetica" !Palatino!Symbol!ZapfDingbatsR!Wingdings!Times!Times New Roman!TektoMM_240 RG 564 NO"TektoMM"Aachen BTAachenDEEMedRAdLib BTAGaramondAldine401 BTAldine721 BTAldine721 Lt BTAlefbetAlexei Copperplate"AlgerianBasDAlgerianBasDEERAlgerianDAllegro BTRAlternateGothic2 BT"Amazone BTBAmelia BTAmericana BTAmericana XBd BTAmericana XBdCn BTAmericanText BTAmericanTypItcDEEBolRAmericanTypItcDEEMedRAmericanUncDAmeriGarmnd BTAmerigo BTAmerigo Md BTAmerType Md BTAnimals 1RAnimals 2RArchitectureArnoldBoeDArriba ArribaArrows1RArrows2RArrus Blk BTArrus BTArsisDEERegRArsisDRegAtlantic Inline"Aurora BdCn BT"Aurora Cn BT"AvantGarde Bk BT"AvantGarde Md BT"AvantGarGotItcTEERAvantGarGotItcTEEDemRAwardsRBakerSignet BTBBalloon Bd BTBalloon Lt BTBalloon XBd BTBalloonsRBangBankGothic Lt BT"BankGothic Md BT"BardBaskervilleOldFacDEERBauerBodDEERBauerBodni BdCn BTBauerBodni Blk BTBauerBodni BlkCn BTBauerBodni BTBauerBodni Titl BTBauhaus Hv BT"Bauhaus Lt BT"Bauhaus Md BT"BauhausITCEEHeaRBauhausItcTEEBolRBauhausItcTEEMedRBedrockBeehiveBellCent Add BT"BellCent BdList BT"BellCent NamNum BT"BellCent SubCap BT" 21. A 30-year-old man came to the outpatient department because he had suddenly developed double vision. On examination it was found that his right eye, when at rest, was turned medially. The most likely anatomical structures involved are: A. Medial rectus and superior division of oculmotor nerve. B. Inferior oblique and inferior division of oculomotor nerve. C. Lateral rectus and abducent nerve. D. Superior rectus and trochlear nerve. Answer: C (Lateral rectus and abducent nerve) Ref: All Anatomy, Most Physiology, All Medicine, All Paediatric, All Ophthalmology, few Surgery books Quality: First MBBS Status: Abused QTDF: First MBBS MCQ Question Papers!!!J Discussion He developed double vision. Right eye turned medially. So there is lateral rectus palsy. So lateral rectus is involved. And the nerve supply of lateral rectus is ??? Explanation Self explanatory. Please refer yourself with the nerve supply of extra ocular muscles. Constraints of space in this small book prevent me from giving these well known facts. Comments No comments. Tips JJust because you see few questions like this dont get a wrong impression about the standard of the question paper and as I have already told you, whenever you get a question that seems so simple, read it once more. (Though not here) There might be a Trap. 22. Which of the following is true about the autonomic nervous system? A. The sympathetic outflow from the CNS is through both the cranial nerves and the sympathetic chain. B. The parasympathetic outflow from the CNS is through the cranial nerves only. C. The superior hypogastric plexus is located at the anterior aspect of the aortic bifurcation and fifth lumbar vertebra. D. The superior hypogastric plexus contains sympathetic fibres only. 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B. This does not come here. C. Portal vein also is not related. D. As seen above, inferior mesenteric vein along with the ascending branch left colic artery are seen in the free edge of paraduodenal fold. Comments A question directly from Gray's Tips Go through the various fossae, recesses and the triangles. 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(xKdd X(xKdddX(xKdddX(xKddd%X(xKdddcX(xKddd ,(xKddthe palmar branch of the median nerve is spared since it does not pass through the carpal tunnel). Lesions of the ulnar nerve Ulnar nerve lesions occur at four sites: A. Behind the medial epicondyle, B. In the cubital tunnel, C. At the wrist and D. In the hand. At the Elbow The ulnar nerve is in a vulnerable position as it lies between the median epicondyle and the olecranon: it lies on bone covered only by a thin layer of skin. It is easily damaged if the ulnar groove is shallow and the nerve may become more prominent than the medial epicondyle or the olecranon when the elbow is fully flexed. Sometimes the nerve may override the medial epicondyle in full flexion. Loss of the ulnar groove may be associated with arthritis of the elbow joint, often due to an old fracture, in which case there may be incomplete extension of the elbow with a wide carrying angle. The nerve is easily palpable and is often thickened. Motor There is usually weakness of flexor digitorum profundus to the ring and little fingers, and if these muscles are involved, the lesion must be at the elbow. Sensory Sensation impaired in: Palmar aspect Medial palmar skin, Medial side of the little finger, Adjoining sides of little and ring fingers Dorsum Medial side of the little finger, Adjacent sides of the little and ring, Adjoining sides of the ring and middle finger. Cubital Tunnel Syndrome This is an entrapment neuropathy of the ulnar nerve in the tunnel formed by the tendinous arch connecting the two heads of flexor carpi ulnaris at their humeral and ulnar attachments. The clinical features are precisely the same as a lesion in the ulnar groove and again, involvement of flexor digitorum profundus to the ring and little fingers is variable. Lesions at these two sites cannot be reliably distinguished neurophysiologically, but in the cubital tunnel syndrome the elbow joint is usually normal: elbow movements are full with a normal carrying angle; the ulnar nerve feels normal in the ulnar groove; it does not sublux; nor does it become superficial on elbow flexion. At the Wrist Site The ulnar nerve may be compressed in Guyons canal by a ganglion. Motor All the small hand muscles innervated by the ulnar nerve are involved. Preservation of flexor digitorum profundus to the ring and little fingers. The dorsal cutaneous branch and the palmar branch of the ulnar nerve are both spared since the lesion is distal to their origin from the main trunk of the ulnar nerve in midforearm. In the Hand The deep motor branch of the ulnar nerve may be compressed against the pisiform and hamate bones when the hand is used as a mallet, or if a vibrating tool or motorcycle handlebar is held in such a way that the hypothenar eminence is off the edge of the handle. The sensory branches are always spared and involvement of the hypothenar muscles is variable depending on the level at which branches to these muscles arise. 19. The nerve commonly damaged during McBurneys incision is: A. Subcostal. B. Iliohypogastric. C. 11th Thoracic. D. 10th Thoracic. Answer: A. (Subcostal) B (Iliohypogastric) Ref: Bailey & Love Surgery 23rd edn, 1091, Says Iliohypogastric Nerve A practical Guide to Operative Surgery by S. Das 4th edn, 270 - says subcostal nerve Short Cases in Surgery by S.Das 2nd edn, 258 says subcostal nerve and Ilioinguinal nerve Quality: Spotter !!! Status: High Yield TopicNerve Injuries QTDF: ???? If we know it, we know the answer!! Discussion Bailey and Love say as hypogastric nerve. Operative surgery Das says that McBurney's incision is safe in the sense that few nerves are injured and if at all a nerve is injured it is the subcostal nerve. Surgical Short Cases by Das says that subcostal and ilioinguinal nerves are involved. Explanation A. Subcostal nerve may be an answer. B. Iliohypogastric nerve also may be the answer. C. This is not the answer. D. This is not the answer. Comments Two books give two views. The question setter knows. Tips Few times we get questions like this when we know that there are two right answers inside the hall (On many occasions, there are two answers but we have happily marked the answer we know, and find that there is another answer and the standard book says that only!!!). When you get questions like this, try to find what book could have been used. For this, scan the other questions from the same subject and the nearby questions and try to find whether you can pick any QTDF in the nearby questions and then go for the answer that book gives. If not, we can safely leave the question (Easier said than done!!). 20. Referred pain from ureteric colic is felt in the groin due to involvement of the following nerve: A. Subcostal. B. Iliohypogastric. C. Ilioinguinal. D. Genitofemoral Answer: D (Genitofemoral) Ref: Gray's Anatomy 38th edn, Abdominal urinary Organsureters, 1833 Quality: Spotter Status: High Yield TopicNerve Supply QTDF: Gray Discussion Clinical Anatomy: As in the case of the gut, excessive ureteric distension or spasm of its muscle provokes severe pain (renal colic), for example, by a stone (calculus) causing incomplete and intermittent obstruction, particularly if it is gradually forced down by the muscle spasm. The pain, spasmodic and agonizing, is referred to cutaneous areas innervated from spinal segments which supply the ureter, mainly T11L2. It shoots down and forwards from the loin to the groin and scrotum or labium majus and may extend into the proximal anterior aspect of the thigh by projection to the genitofemoral nerve (L1, 2); the cremaster (which has the same innervation) may reflexly retract the testis. Explanation A. Subcostal is not our nerve. B. Iliohypogastric also is not the answer. C. This is a confusa. D. Genitofemoral nerve is the answer as per Gray's Anatomy. Comments There were (and are) few who say that the answer is ilioinguinal, but in my opinion, when Grays Anatomy says a point we have to accept it without arguing. Remember that Gray enjoys a position unparalleled in the enire (never ending) list of books used by a doctor. For no other subject we have a book that is accepted as the Gold Standard in all parts of world. (As far as India is concerned, PARK is the Emperor). Tips A ureteric stone is liable to impact at one of the ureteric constrictions, namely (1) its superior end, (2) where it crosses the brim of lesser pelvis or (3) as it passes through the vesical wall; radiologically, it would appear near the tip of the second lumbar transverse process, overlying the sacro-iliac joint, or slightly medial to the ischial spine. Sometimes the ureter is duplicated on one or both sides even as far as the bladder; separate vesical openings are rare in such cases. 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Neroenteric cyst is present in the posterio16. In a patient with a tumor in superior mediastinum compressing the superior vena cava, all the following veins would serve as alternate pathways for the blood to return to the right atrium, except: A. Lateral thoracic vein. B. Internal thoracic vein. C. Hemiazygos vein. D. Vertebral venous plexus. Answer: D (Vertebral venous plexus). Ref: Grays Anatomy 38th edn, 1594; Fundamentals ofHuman Anatomy (Regional and Applied) Dr AS Moni -Vol II, 46 deals with the alternate pathways for SVC Obstruction; McGregors Surgical Anatomy: Fig 182,183,236,237; Snells Clinical Anatomy 6th edn, 276,140,105 Quality: Thinker Status: New QTDF: ?? Discussion SVC obstruction above the opening of azygos vein A. SVC Brachocephalic Subclavian Internal Thoracic Sup Epigastric Inf Epigastric Ext iliac Common Iliac IVC Right Atrium B. SVC Brachocephalic Subclavian Internal Thoracic Ant Intercostal Posterior Intercostal Azygos, Hemiazygos, Acc Hemiazygos SVC Right Atrium C. SVC Brachocephalic Subclavian Lateral Thoracic Thoraco Epigastric IVC Right Atrium SVC obstruction below the opening of azygos vein A. SVC Azygos Veins on Ant Abd Wall and Lat Thoracic Vein Epigastric Vein IVC Right Atrium In obstruction of the upper inferior vena cava, the azygos and hemiazygos veins and vertebral venous plexuses are the main collateral channels maintaining venous circulation, by connecting superior and inferior venae cavae and communicating with the common iliac by ascending lumbar veins and with many tributaries of the inferior vena cava. Explanation A. Lateral thoracic vein is a collateral pathway in SVC obstruction. B. Internal thoracic vein is a collateral pathway in SVC obstruction. C. Hemiazygos vein is a collateral pathway in SVC obstruction. D. Vertebral venous plexus is a collateral pathway in IVC obstruction. Comments A question which requires thorough knowledge to solve. Tips Another topic of importance is the portosystemic anastomosis. 17. All of the following features can be observed after the injury to axillary nerve, except: A. Loss of rounded contour of shoulder. B. Loss of sensation along lateral side of upper arm. C. Loss of overhead abduction. D. Atrophy of deltoid muscle. Answer: C (Loss of overhead abduction) Ref: Grays Anatomy 38th edn, 1269; McGregor, 12th edn, 439 Quality: First MBBS Status: Repeatfrom the High Yield TopicNerve Injuries QTDF: All anatomy books !!! Discussion Lesions of the Axillary Nerve: The most common causes of axillary nerve lesions are trauma and neuralgic amyotrophy. A. There is wasting of deltoid. B. Weakness of deltoid, which is usually clinically evident, and C. A patch of sensory loss on the outer aspect of the arm. (called the Regimental Badge Area). This can be differentiated from a C5 root lesion by finding normal function in the distribution of the suprascapular nerve. Abduction: Abduction is initiated by the supraspinateus 0 to 15 degree and the humerus moves over glenoid (Glenohumeral). Then from 15 to 90 degree the arm is abducted by deltoid and the humerus moves over glenoid (Scapulothoracic). Further abduction above 90 degrees (Hyperabduction is done by the trapezius and serratus anterior which rotate the scapula. Explanation A. Loss of rounded contour of shoulder is due to the wasting of deltoid. B. Loss of sensation along lateral side of upper arm, the regimental badge area is supplied by the axillary nerve. C. Loss of overhead abduction does not occur. Because the overhead abduction is by the movement of scapula and not by the movement of humerus over glenoid. D. Atrophy of deltoid produces the loss of rounded contour of the shoulder Comments See another question from the high yield topicnerve injuries. Tips Read the sensory supply of the important peripheral nerves. 18. Injury to radial nerve in lower part of spiral groove: A. Spares nerve supply to extensor carpi radialis longus. B. Results in paralysis of anconeus muscle. C. Leaves extension at elbow joint intact. D. Weakens pronation movement. Answer: k$ 0񄋋D_-kD'|x%A\Pb '\P-kDlGáD*w-kDLD*w-kH!0Pp0PP l0񄋋D_-kD'|x%A\Pb0񄋋D_-kD'|x%A\Pb0߸pP0PP  mPJ0񄋋D_-kD'|x%A\Pb '\P-kDlGáD*w-kDLD*w-kH!0Pp0PP n0񄋋D_-kD'|x%A\Pb0񄋋D_-kD'|x%A\Pb0߸pP0PP ot>0񄋋D_-kD'|x%A\Pb '\P-kDlGáD*w-kDLD*w-kH!0Pp0PP p0񄋋D_-kD'|x%A\Pb0񄋋D_-kD'|x%A\Pb0߸pP0PP q O0񄋋D_-kD'|x%A\Pb '\P-kDlGáD*w-kDLD*w-kH!0Pp0PP r0񄋋D_-kD'|x%A\Pb0񄋋D_-kD'|x%A\Pb0߸pP0PP s@0񄋋D_-kD'|x%A\Pb '\P-kDlGáD*w-kDLD*w-kH!0Pp0PP t0񄋋D_-kD'|x%A\Pb0񄋋D_-kD'|x%A\Pb0߸pP0PP C (Leaves extension at elbow joint intact) Ref: Snells 6th, 493; AK Dutta,66; BDC Vol 1, 90; Grays Anatomy 38th edn, 1274 Quality: Reader Status: Repeat QTDF: All books Discussion BDC describes the branches of radial nerve only under the following headings: A. Before spiral groove Long head of triceps Medial head of triceps B. In spiral groove Long head of triceps Lateral head of triceps Medial head of triceps Ancomeus C. After spiral groove Brachialis Brachoradialis Extensor carpi radialis Gray describes the muscular branches as below: These supply the triceps, anconeus, brachioradialis, extensor carpi radialis longus and brachialis in medial, posterior and lateral groups. A. Medial muscular branches Arise from the radial nerve on the medial side of the arm. They supply the: Medial head of tricepsthe branch to the medial being a long, slender filament which, lying close to the ulnar nerve as far as the distal third of the arm, is often termed the ulnar collateral nerve. Long heads of the triceps, B. A large posterior muscular branch: Arises from the nerve as it lies in the humeral groove. It divides to supply the Medial and Lateral heads of the triceps and the Anconeus, that for the latter being a long nerve which descends in the medial head of the triceps and partially supplies it; it is accompanied by the middle collateral branch of the arteria profunda brachii and passes behind the elbow joint to end in the anconeus. C. Lateral muscular branches: Arise in front of the lateral intermuscular septum; Supply the Lateral part of the brachialis, Brachioradialis and Extensor carpi radialis longus. So, in any injury in the lower part of spiral groove, we have to assume that the posterior muscle branch has escaped. So triceps will not be affected and Anconeus has its nerve supply intact. Lesions of Radial Nerve At axilla  Loss of elbow extension Loss of sensation in the lateral and posterior part of arm Loss of wrist extensionWrist drop Loss of thumb extensionThumb drop Loss of finger extensionFinger drop Loss of sensation in the first dorsal web space At the lower end of spiral groove Loss of wrist extensionWrist drop Loss of thumb extensionThumb drop Loss of finger extensionFinger drop Loss of sensation in the first dorsal web space After spiral groove before piercing the supinator and before the origin of sensory branch Diminished wrist extensionWrist deviates radially when extended Loss of thumb extension Thumb drop Loss of finger extensionFinger drop Loss of sensation in the first dorsal web space After piercing the supinator (posterior interosseus nerve) Loss of thumb extensionThumb drop Loss of finger extensionFinger drop Superficial branch It lies superficially and relatively unprotected overlying the lateral aspect of the radius, where it is easily compressed by tight bracelets, watch straps and handcuffs, called Cheralgia Paraesthetica (compare with Meralgia Paraesthetica) Loss of sensation in the first dorsal web space If the lesion is proximal in this nerve, sensation may be impaired over a variable area of skin over the lateral side of the dorsum of the hand. Explanation A. Nerve supply to extensor carpi radialis longus is not spared B. Does not result in paralysis of anconeus muscle as the posterior muscle branch escapes because it arises in the spiral groove and the injury is in the lower part of the spiral groove. C. Leaves extension at elbow joint intact as the triceps is supplied by medial and posterior branches both of these arise above the lower part of spiral groove D. Does not weaken the pronation. In fact, it is the only movement not supplied by radial nerve. Comments The catch in this question is the lower part of spiral groove. If the same injury has happened in the spiral groove, then anconeus will be paralysed and extension of elbow will not be intact. Then we have to go for choice B. Radial nerve extends, flexes (by supplying bracho radialis, which is morphologically a extensor and functionally a flexor and brachialis which has a dual nerve supply along with musculocutaneous nerve) and also supinatesbut it does not supply pronation. Tips Other nerve injuries: Lesions of the median nerve Median nerve lesions occur at two sites: A. In the forearm (Pronator syndrome) and B. At the wrist. (Carpal tunnel syndrome) Pronator Syndrome This is an uncommon entrapment neuropathy of the median nerve. Sites The nerve may be involved at any of these sites: 1. As it passes alongside the fibrous band connecting the biceps tendon to the forearm fascia. 2. As it passes down between the two heads of pronator teres. 3. As it passes through a fibrous arch formed by flexor digitorum superficialis. Symptoms and Signs Motor There is weakness of all the muscles innervated by the median nerve, including abductor pollicis brevis and the long finger flexors. Sensory There is also sensory impairment on the palm of the hand (spared in the carpal tunnel syndrome because the palmar cutaneous branch of the median nerve arises above the carpal tunnel and lies superficial to) Anterior Interosseous Nerve Palsy The anterior interosseous nerve usually arises from the median nerve proximal to the site of compression in the pronator syndrome; it may be affected with the median nerve or by itself. Causes A. Due to external pressure (a form of Saturday night palsy), B. Sometimes by tight grip in association with pronation without obvious cause. C. May be a manifestation of neuralgic amyotrophy and tends to resolve spontaneously over several months. Motor An anterior interosseous nerve palsy causes weakness of pinch grip due to involvement of flexor pollicis longus and flexor digitorum profundus to the index finger. Please note that: Innervation of flexor digitorum profundus to the middle finger is rather variable, (also by ulnar nerve) therefore, this muscle may or may not be weak. The branches to these three muscles (FDP, FPL, PQ) may arise separately from the median nerve, so that isolated weakness of the terminal phalanx to the thumb or index finger may occur. The pronator quadratus is also involved but is not clinically significant. Carpal Tunnel Syndrome This is the most common entrapment mononeuropathy caused by the compression of the median nerve as it passes through the fibro-osseous tunnel beneath the flexor retinaculum. Causes The carpal tunnel may be narrowed by: A. Arthritic changes in the wrist joint, particularly rheumatoid arthritis; B. Soft tissue thickening as may occur in myxoedema and acromegaly; C. Oedema and obesity including pregnancy. Pathology Normally, the nerve slides smoothly in and out of the carpal tunnel with flexion and extension of the wrist; when the nerve is compressed, there is an additional damage to the nerve with flexion and extension. The dominant hand is usually affected first, probably because this hand is used more frequently and more vigorously. Motor There is wasting and weakness of abductor pollicis brevis: Sensory Impairment of sensation in the: A. Thumb, B. Index finger, C. Middle finger and D. 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Tumor markers of hepatocellular carcinoma include a. CEA b. Des gamma carboxyprothrombin c. CA 19-9 d. Fucosylated alpha protein e. Alpha fetoprotien elevated in greater than 70% Ref:: HPIM 579, CMDT 689 fffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffhttp://www. intouchlive. com/consults/ccn9903b. htm Quality:spotter thinker reader BATA Discussion Alpha fetoprotein levels raised in Cirrhosis Massive liver necrosis Chronic hepatitis hepatocellular carcinoma Normal pregnancy Fetal distress or death Fetal neural tube defects-enencephaly & spina bifida Gonadal germ cell tumours teratoblastoma, Levels above 1000 ng/ml HCC CEA (Carcino Embryonic Antigen) elevated in: malignancies of the gastrointestinal tract (pancreas, colon, rectum), lung, breast, prostatic and ovary. inflammation and heavy smoking. CA-125 normally found in adult female fallopian tube, endometrium and endocervix. CA-15 elevated breast and lung cancer. . CA-199 elevated in intra-abdominal carcinomas, adenocarcinomas of the lung, gastric, biliary and colonic neoplasms. Explanation a. serum CEA levels alone are not specific for hepatocellular carcinoma but are nonetheless raised. correct choice. b. Des gamma carboxyprothrombin, an abnormal typre of [rothrombin which correlates with h levels of AFP. c. CA 19-9 levels are elevated in HCC. D most of the patients with hepatocellular carcinoma have an elevated serum concentration of fucosylated alpha-fetoprotein. correct choice. e. Alpha-fetoprotein elevated in greater than 70% . true. Correct choices A bcde 67. Which of the following are causes of posterior mediastinal mass: A. Neuroenteric cyst B. Neurogenic cyst C. Anterior thoraxic meningocele D. Lymphoma E. Bronchogenic cyst Anterior mediastinum: Middle Mediastinum: Posterior mediastinum: Germ cell neoplasm Lymphoma: Morgagni hernia Pericardial cyst Thymic lesions: Thyroid (Retrosternal goiter) Foregut duplication cysts Castlemans disease Lymphangioma Lymphoma Bronchogenic cyst Bochdalek Hernia Extramedullary Hematopoiesis Ganglioneuroma Ganglioneuroblastoma Neuroblastoma Lateral thoracic meningocele Malignant tumor of nerve sheath origin Neurofibroma Paraganglioma Pheochromocytoma Schwannoma Explanation A. Neuroenteric cyst is present in the posterior mediastinum or paravertebral area. B. Neurogenic cyst is present in the posterior mediastinum C. Anterior thoracic meningocele is present in the posterior mediastinum D. Lymphoma is a tumour of the middle or anterior mediastinum E. Bronchogenic cyst is a tumour of the middle mediastinum. Correct choices Abc 213. Peripheral neuropathy is seen in all of the following except a. Tuberculosis b. Polyarteritis nodasa c. Diabetes mellitus d. SLE 89. Diabetes mellitus is associated with all of the following except: a. Neuropathy b. Encephalopathy c. Myopathy d. Myelitis e. Myelopathy Ref: CMDT 1191,HPIM 2481 Quality:spotter thinker reader BATA Discussion Diabetic neuromuscular involvement may manifest as: A. Distal symmetric polyneuropathy B. Isolated peripheral neuropathy-mononeuropathy C. Mononeuritis multiplex D. Painful neuropathy 5. Autonomic neuropathy 6. Cranial neuropathypainful opthalmoplegia 7. Diabetic amyotrophy/proximal neuropathy/lumbosacral plexopathy 8. Ischemic myopathy of thigh muscles D e 127. In carbon monoxide toxicity a. There is left shift of oxygen dissociation curve b. Saturation of oxygen at 50% PaO2 is decreased c. Oxygen content of arterial blood is decreased d. Induces a state of metabolic acidosis e. Oxygen is used in treatment Ref: Ganong 17th 633 Quality:spotter thinker reader BATA Discussion Explanation a. There is left shift of oxygen dissociation curve. COHb shifts the curve of the remaining HbO2 to left decreasing the amount of O2 released by the normal saturated Hb. b. Saturation of oxygen at 50% PaO2 is decreased. I think this choice should be saturation of Hb at given PO2 is decreased which is untrue because the curve shifts to the left. This increases the saturation of Hb at givenPO2 and even makes the available HbO2 useless for oxygenation because it wont release the O2. c. Carboxu Hb reduces oxygen transportation by Hb thus Oxygen content of arterial blood is decreased. correct. d. Induces a state of metabolic acidosis because of the hypoxia e. Ventilation with O2 is preferable to ventilation with fresh air since O2 hastens the dissociation of COHb. Hyperbaric O2 is useful. Correct choices A c d e b3bf3727974b27b7d4e8c3 CXcaD CXca0 CX@@,C@B># C@@Cc)C@ CC@B, C<#*C @@, Cca:.CX caN%CX1 caD&CX ca0&CX @@, Cz>#CIca:CXcaNCXo caDCX ca02+Xh CXK@@,Cr;# CcC,Cpca6<#hX2Ch@B<ca: CXcaNCX?caDCXca0CX6@@,C@B4C@@Cc)C@ CC@B, C;#A#=#<#0#:#;#;#"C` c7#,1#?#C#@#2#<#;#8#A#=#8# Cdc4#,:#;#A#>#@#B##B#H#G#@#Cfc5#,:#<#>#=#<Cc:#,=#2C@B, Cca:5#Xh CXUcaN8#Xh7#Xh8+Xh8#Xh7#Xh2#Xh8#Xh7+Xh5+Xh CXcaD8#Xh9+Xh7#Xh4#Xh5+Xh:+Xh6#Xh#CX ca04#Xh;#Xh3#Xh4+Xh6#Xh7#Xh6#Xh'CX3 @@,C Cz/Cac7#,@#=#=#<#=#8#;#A#C@@,Cr;#9CCCCCpffffffffffffffffffffffffffffffff 52. True about calcium is/are a. Entry is regulated by calmodulin uptake b. Extracellular concentration of calcium is 10,000 times more than intracellular c. Symport uptake d. Entry into cell is passive c. Released by sarcoplasmic reticulum Ref:: ganong 35, Quality:spotter thinker reader BATA Discussion Explanation Correct choices: b, e . 3. Which of the following are organophosphates: A. dieldrin B. parathion C. malathion D. Kepone 5. Propoxur Ref::Trip 5th Page 81 Park 550 table Quality:reader Discussion Explanation: anticholinesterases Reversible Carbamates Acridine Physostigmine (Eserine) Neostigmine Pyridostigmine Edrophonium Rivastigmine Donepezil tacrine Irreversible Organophosphates Carbamates Dyflos DFP Echothiophate Parathion Malathion Diazinon TIK 20 Tabun Sarin Soman Carbaryl (Sevin) Propoxur(Baygon) Explanation A. dieldrin-organochlorine pesticide. incorrect choice. B. parathionirreversible OPC. correct choice. C. malathion irreversible OPC. correct choice D. Kepone/chlordecone- organochlorine pesticide. incorrect choice pesticide 5. Propoxurirreversible carbamates. incorrect choice Correct choices: b c 203. Which of the following are features of spinal shock a. Spasticity b. urinary retention c. Areflexia d. Sensory level e. Increased DTRs Ref::clinical acumen Quality:spotter thinker reader BATA Discussion Spinal shock(neuronal) is the initial state just after an acute insult causing an uMN lesion caused by the temporary depressant effect on the anterior horn cells. Characterized by paralysis,areflexia,flaccidity,the chracteristic hypertonia and increased relexes of cotticospinal lesion appear after few hrs-days. Explanation Correct choices B C d 217. Which of the following predispose a patient to prehepatic encepalopathy a. Constipation b. Bacterial peritonitis c. Hemorrhage d. Hyperkalemia e. Dehydration Ref: HPIM 1715 Quality:spotter thinker reader BATA Discussion Common precipitants of hepatic failure Increased nitrogen load GIT bleeding Excess dietary protein Azotemia Constipation Electrolyte & metabolic imbalance Hypokalemia Alkalosis Hypoxia Hyponatremia Drugs Narcotics and Tranqulizers Sedatives Diuretics Miscellaneous Infection surgery Superimposed acute liver disease Progressive liver disease Explanation: A. Constipation B. Bacterial peritonitis being an infection. correct choice. C. Hemorrhage D. Hyperkalemia: Hypokalemia not Hyperkalemia is known to worsen hepatic Encephalopathy. 5. Dehydration can cause hypovolemia & electrolyte disturbances that can ppt. hepatic Encephalopathy Correct choices: a b c e 8. the drugs useful in the treatment of ectopic pregnancy is A. Methotrexate B. Actinomycin D C. Cyclophosphamide D. Potassium fluoride 5. Adriamycin Ref:: Dutta 202 Quality: spotter Explanation A. Methotrexate: used in medical therapy. correct choice. B. Actinomycin D. correct choice. C. Cyclophosphamide. Incorrect choice. D. Potassium fluoride: potassium chloride is used in ectopic pregnancy. Incorrect choice. 5. Adriamycin is not used in ectopic pregnancy. Correct choices A b 210. Adventitial bursitis due to tuberculosis is found in which of the following sites commonly a. Prepatellar b. Greater trochanter of femur c. Sub acromial d. Metatarsal e. Sub olecranon 209. Snow ball opacities in vitreous is seen in which of the following a. Parsplanitis b. Rheumatoid arthritis c. Anterior unietis d. Retinitis pigmentosa e. Endothelial dystrophy Ref: http://www. indmedica. com/cos/journal/vasculitis. html Quality:spotter thinker reader BATA Explanation A. Parsplanitis is characterized by snowball opacities. B. Rheumatoid arthritis is one of the causes of pars planitis hence may show snow ball opacities C. Anterior uveitis D. Retinitis pigmentosa 5. Endothelial dystrophy Correct choices: A b 77. The left border of the heart is formed by a. Pulmonary Artery b. Pulmonary vein c. Right ventricle d. Ascending aorta e. Arch of aorta Ref:: BDC 226,Grays 38th 1476 Quality: spotter thinker reader BATA Discussion Anatomically Right border is formed by RA. Left border of heart is formed by LA and LV. upper border formed by LA, asc aota & pul trunk infron of it. Inferior border of the heart is formed by RV and contribution of LV at the apex. Correct choices NONE OF THE CHOICES ARE CORRECT Or 77. left border of the heart in chest XR is formed by a. pul artery b. pul vein c. abdominal aorta d. arch of aorta e. right ventricle Quality: :reader Reference: Discussion: Borders of cardiac silhouette on PA view Right border from above downwards Superior vena cava Outer border of R atrium Sometimes asc, arch of aorta & inferior vena cava Left border from above downwards Aortic knuckle Pul. 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(xKdd (xKdd| (xKdd (xKddt (xKdd ,(xKddW (xKddEX(xKdddUX(xKdddLX(xKddd&X(xKddd ,(xKddf (xKdd ,(xKddt (xKddOh<(xKddd&X(xKddd*X(xKddd'X(xKdddDX(xKddd ,(xKdd& ,(xKdd (xKdd (xKdd (xKdd- (xKdd (xKdd (xKddGray Discussion The hypogastric plexus is situated in front of the last lumbar vertebra and the promontory of the sacrum, between the two common iliac arteries, and is formed by the union of numerous filaments, which descend on either side from the aortic plexus, and from the lumbar ganglia; it divides, below, into two lateral portions which are named the pelvic plexuses. This plexus supplies the bladder, rectum and internal and external genitalia. Explanation A. The sympathetic outflow from the CNS is through the sympathetic chain by the thoraco lumbar outllow and so this choice is wrong. B. The parasympathetic outflow from the CNS is through both the cranial nerves and from the sacral part of the spinal cord and thus this choice is also wrong. C. The superior hypogastric plexus is located at the anterior aspect of the aortic bifurcation and fifth lumbar vertebra and this is correct. Another relation here is the sacral plexus. D. The superior hypogastric plexus contains sympathetic fibres as well as parasymphathetic fibres and so this choice is wrong. Comments The first two choices are too simple and even a school student knows that this is not the answer. Read the basics of autonomic system. Autonomic system will account for 5 % of questions in any MCQ Exam (Questions will come in such varying topics as Anatomy, Physiology, Metabolism of Tyrosine, Anticholinergics, Glaucoma, Allergic Rhinitis, Addiction, Hypertension, Critical Care, Asthma, Preterm labour and what not !!!) Details should me mastered from Tripathi for this topic. Tips Another high yield topic is acid-base balance. 23. The lumbar region of the vertebral column permits all of the following movements, except: A. Flexion B. Extension C. Lateral flexion D. Rotation Answer: D (Rotation) Ref: Grays Anatomy 38th edn, 515 Quality: Reader Status: High Yield TopicMovements QTDF: Grays Anatomy 38th Edition Page 515 Discussion Movements of vertebral column 1. Flexion : More in cervical 2. Extension : More in cervical and lumbar and least in thoracic 3. Lateral flexion : In all areas, but greatest in cervical and lumbar 4. Rotation : Slight at cervical, greatest at thoracic and least in lumbar 5. Circumduction : A succession of preceding movements Explanation A. Flexion occurs. B. Extension also occurs. C. Occurs and is greatest here. D. Rotation is least here and is most in the thoracic vertebra. Comments This question could have been solved by logic also. Tips Remember that spine and spinal cord anatomy is a favourite topic for MCQ setters and here you need not memorise the entire facts. Few basic concepts will do. 24. All of the following are examples of traction epiphysis, except: A. Mastoid process. B. Tubercles of humerus. C. Trochanters of femur. D. Condyles of tibia. Answer: D (Condyles of tibia) Ref: Principles of General Anatomy, AKDatta, 44; Grays Anatomy 38th Edition Quality: Thinker Status: New Question QTDF: Gray Discussion Many bones have epiphyses at both ends, others at one end only. Long limb bones show the former, while the metacarpals, metatarsals, phalanges, clavicles and ribs have only one epiphysis, though the costal cartilages may represent epiphyses normally devoid of ossification centres. Epiphyseal ossification is sometimes more complex; for example, the proximal end of the humerus, wholly cartilaginous at birth, develops three centres during childhood, which coalesce into a single mass before fusing with the diaphysis. Only one of these centres forms an articular surface, the others forming the greater and lesser tubercles giving muscular attachments. Similar composite epiphyses occur at the distal end of the humerus and in the femur, ribs and vertebrae. Epiphysis Due to At For example Pessure Exposed to articular pressure Articular ends Head of femur epiphyses Transmitting the weight of the bones Lower end of of the body from bone radius to bone Traction Muscular traction Insertion and Tubercles of epiphyses origin of humerus muscles Trochanters of femur Mastoid process Atavistic Representing parts of the A small centre in epiphyses skeleton, which at one time the human formed separate bones, but coracoid process which have lost their epiphysis at the function, and only appear medial end of the as separate ossifications clavicle in early life Few books describe an aberrant epiphysis as well (Epiphysis which is not always presentHead of first metacarsal) Explanation The answer is D because all other 3 are formed by traction of a muscle attached to it A. Mastoid processformed by the traction of sterno cleido mastoid. B. Tubercles of humerusformed by the traction of SITS group and pectoralis major. C. Trochanters of femuryou know the long list of muscles attached there. D. This is not a traction epiphysis. Comments Please note that traction epiphysis has nothing to do with the skin and pin traction in orthopaedics. Tips Embryology is another area of anatomy where you can get questions that when answered by Guess often goes wrong. 25. All of the following statements are true for metaphysis of bone, except: A. It is the strongest part of bone. B. It is the most vascular part of bone. C. Growth activity is maximised here. D. It is the region favouring haematogenous spread of infection. Answer: A (It is the strongest part of bone) Ref: Grays Anatomy 38th edn, 441; Maheswari (Ortho) 2nd edn, 156; Principles of General Anatomy, AK Datta, 45 Quality: Reader Status: New Question QTDF: Datta Discussion Metaphysis, as we all know, is the most metabolically active part of the bone with rapid cell turn over and most vascular part also. Since it is the most vascular part, we have the osteomyelitis that spreads through haematogenous route originate here in children and is one of the areas that get fractured in pathological fractures of the bone. The zone of maturation is more vulnerable. Explanation A. It is the weakest part of bone and so this is a wrong statement. B. It is the most vascular part of bone. C. Growth activity is maximized here. D. It is the region favouring hematogenous spread of infection. Comments Read the relevant chapters on osteomyelitis in a orthopaedics book and you will get a solid idea Tips Remember that the zone of maturation is a weak spot in the bone. 26. All of the following muscles are grouped together as muscles of mastication, except: A. Buccinator. B. Masseter. C. Temporalis. D. Pterygoids. Answer: A (Buccinator) Ref: Grays Anatomy 38th edn, 799; BDC 3rd Edition Volume III Page 115 Quality: Spotter Status: Repeat QTDF: All anatomy books Discussion The muscles of mastication are the masseter, the temporalis and the medial and the lateral pterygoids Explanation A. Buccinator is a muscle of facial expression. B. Masseter is a muscle of mastication. C. Temporalis is a muscle of mastication. D. Pterygoids are muscles of mastication. Comments Buccinator is a muscle of facial expression. Few points worth mentioning about this are: A. 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Molecular Exclusion Chromatography Also known as gel permeation or gel filtration, this type of chromatography lacks an attractive interaction between the stationary phase and solute. The liquid or gaseous phase passes through a porous gel which separates the molecules according to its size. The pores are normally small and exclude the larger solute molecules, but allows smaller molecules to enter the gel, causing them to flow through a larger volume. This causes the larger molecules to pass through the column at a faster rate than the smaller ones. [* | In-line.WMF 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Affinity Chromatography This is the most selective type of chromatography employed. It utilizes the specific interaction between one kind of solute molecule and a second molecule that is immobilized on a stationary phase. For example, the immobilized molecule may be an antibody to some specific protein. When solute containing a mixture of proteins are passed by this molecule, only the specific protein is reacted to this antibody, binding it to the stationary phase. This protein is later extracted by changing the ionic strength or pH. [* | In-line.WMF 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Tips Question. 45. The substances present in the gall bladder stones or the kidney stones can be best identified by the following technique: A. Fluorescence spectroscopy. B. Electron microscopy. C. Nuclear magnetic resonance. D. X-ray diffraction. Answer D. X ray diffraction Ref: Harper,25th Edtion Pg-56 may appear to indicate NMR but Harper 25th Edition Pg 55 Harper 24th Edition Pg10 : The most detailed information is by X-Ray Diffraction and Crystallography Harrison 15th Edition Chapter 322 -GOUT AND OTHER CRYSTAL ARTHROPATHIES Harrison 15th Edition Chapter 327 Principles of Endocrinology Campbells Urology 8th Edition Page 3274 mention option 4 as the investigating modality in revealing structures of microcrysta Quality: Spotter If you had already read the Ref:s shown above Status: New QTDF: Harrison Discussion The use of polarizing microscopy during synovial fluid analysis and the application of other crystallographic techniques, such as electron microscopy, energy-dispersive elemental analysis, and x-ray diffraction, have established the role of different microcrystals, including monosodium urate (MSU), calcium pyrophosphate dihydrate (CPPD), calcium hydroxyapatite (HA), and calcium oxalate (CaOx), in inducing acute or chronic arthritis or periarthritis. The family of nuclear receptors has grown to nearly 100 members, many of which are still classified as orphan receptors because their ligands, if they exist, remain to be identified . Otherwise, most nuclear receptors are classified based on the nature of their ligands. Though all nuclear receptors ultimately act to increase or decrease gene transcription, some (e.g., glucocorticoid receptor) reside primarily in the cytoplasm, whereas others (e.g., thyroid hormone receptor) are always located in the nucleus. After ligand binding, the cytoplasmically localized receptors translocate to the nucleus. The structures of nuclear receptors have been extensively studied, including by x-ray crystallography. X-ray crystallography shows that various SERMs induce distinct receptor conformations. Explanation 1 .Fluorescence spectroscopy: When a primary x-ray excitation source from an x-ray tube or a radioactive source strikes a sample, the x-ray can either be absorbed by the atom or scattered through the material. The process in which an x-ray is absorbed by the atom by transferring all of its energy to an innermost electron is called the photoelectric effect. During this process, if the primary x-ray had sufficient energy, electrons are ejected from the inner shells, creating vacancies. These vacancies present an unstable condition for the atom. As the atom returns to its stable condition, electrons from the outer shells are transferred to the inner shells and in the process give off a characteristic x-ray whose energy is the difference between the two binding energies of the corresponding shells. Because each element has a unique set of energy levels, each element produces x-rays at a unique set of energies, allowing one to non-destructively measure the elemental composition of a sample. The process of emissions of characteristic x-rays is called X-ray Fluorescence, or XRF. Analysis using x-ray fluorescence is called X-ray Fluorescence Spectroscopy. In most cases the innermost K and L shells are involved in XRF detection. A typical x-ray spectrum from an irradiated sample will display multiple peaks of different intensities. This is similar to the absorbtion spectrometry we use for determining the various forms of Hemoglobin (given in Chaterjee Biochemistry and Narayana Reddy FM Blood stains) but instead of the visible light we use in Hb determination, we use X-Rays here B. Electron microscopy.: Electron Microscopes are scientific instruments that use a beam of highly energetic electrons to examine objects on a very fine scale. This examination can yield the following information: Topography : The surface features of an object or how it looks, its texture; direct relation between these features and materials properties (hardness, reflectivity...etc.) Morphology : The shape and size of the particles making up the object; direct relation between these structures and materials properties (ductility, strength, reactivity...etc.) Composition : The elements and compounds that the object is composed of and the relative amounts of them; direct relationship between composition and materials properties (melting point, reactivity, hardness...etc.) C. Nuclear magnetic resonance spectroscopy is a powerful and theoretically complex analytical tool technique used for determining the content and purity of a sample as well as its molecular structure. For example, NMR can quantitatively analyze mixtures containing known compounds. For unknown compounds, NMR can either be used to match against spectral libraries or to infer the basic structure directly. Once the basic structure is known, NMR can be used to determine molecular conformation in solution as well as studying physical properties at the molecular level such as conformational exchange, phase changes, solubility, and diffusion. In order to achieve the desired results, a variety of NMR techniques are available. D. X-ray diffraction The term x-ray diffraction refers to the diffraction of x-rays by a crystal. The wavelengths of x-rays are comparable in size to the distances between atoms in most crystals, and the repeated pattern of the crystal lattice acts as a diffraction grating for x-rays. Comments The term x-ray powder diffraction refers in general to x-ray diffraction of a collimated monochromatic beam by a sample (a powder) containing a large number of tiny crystals having random orientations. The term x-ray crystallography refers to the use of x-ray diffraction to determine the structure of crystals or molecules. In general, the technique involves directing a beam of x-rays at a crystalline sample and recording the diffracted x-rays on a photographic plate. The x-ray diffraction pattern consists of a pattern of spots on the plate, and the crystal structure can be determined from the positions and intensities of the diffraction spots. Since x-rays are diffracted by the electrons in a molecule, if molecular crystals of a compound are used, the electron density distribution in the molecule can be determined. X-ray diffraction is currently one of the most important tools of solid-state physics and chemistry, the technique used for differentiation between crystalline and amorphous materials, determination of the structure of crystalline materials, determination of electron distributions within atoms and throughout unit cells of a crystal, determination of the orientation of single crystals, determination of the texture of polygrained materials, etc. In the biological sciences, x-ray diffraction has contributed greatly to our understanding of processes occurring in living cells, with the technique revealing the structures of proteins and nucleic acids and their constituent monomers, and also of drugs, hormones, and vitamins. Knowledge of 3-dimensional structures of various biomolecules has had a profound impact on the whole of biology. Tips Question. 46. Porphobilinogen in urine produces pink color with: A. Fouchets reagent. B. Benedicts reagent. C. Sodium nitropruside. D. Ehrlich s aldehyde reagent. Answer D. Ehrlich s aldehyde reagent. Ref: J.Sengupta,SynopsisOfClinicalPathology&Microbiology,5th,Pg-82 Textbook of Medical Biochemistry 4th Edition Chaterjee and Shinde Page 477 Chaterjee and Sinde 2nd Edition Page 322 Chapter on Porphyrias Quality: Spotter Status: New QTDF: Chaterjee Discussion Watson and Schwartz Test for Porphobilinogen Procedure A. Mix Equal Volume of Fresh urine and Ehrlich Reagent (0.7 gm of p-dimethyl amino benzaldehyde + 150 ml of Conc HCl and 100 ml Distilled water) B. Allow to stand for 3 minutes C. To this add saturated aqueous Sodium Acetate Solution (2 volumes) and D. Leave for 3 minutes 5. Add a few ml of Chloroform 6. Shake thoroughly 7. Porphobilinogen forms a red aldehyde compound which (unlike that formed by urobilinogen) is insoluble in Chloroform Interpretation: Red colour after second extraction with chloroform means a positive test for Porphobilinogen and highly suggestive of Acute Intermittent Porphyria. On the other hand if the chloroform becomes pink it is Urobilinogen Explanation A. Fouchets reagent detects bile pigments. B. Benedicts reagent All of you will know one Benedicts reagent, but there is another also !!! (See Uric Acid in the Table Below) C. Sodium nitropruside is used along with Ammonium Sulphate for detection of Ketones in Rohtera Test. D. Ehrlich s aldehyde reagent. Is used as above Comments The table below is incomplete and should not be used for studying. A complete table is beyond the scope of this book, but may be found at www.rxpg.com, www.rxpgonline.com and www.targetpg.com. This is for refreshing your memory. Only the reagents are dealt with and the procedures are not given for want of space Few points about Urine Analysis Substance Detected Name of the Test Reagent Colour Chloride Fantus AgNO3 White Sulphate Acetic Acid, BaCl2 White Ethereal Sulphates Acetic Acid, BaCl2 ,HCl Turbidity Indiacan Jaffe Hypochlorite(K Chlorate and Conc HCl) Extract with Chloroform Indigo blue Oberneyers Ferric Chloride + HCl Extract with Chloroform Indigo blue Calcium Sulkowich Oxalic Acid, Ammonium Oxalate and Glacial Acetic Acid Fine white cloud or Heavy Milky White Urea Hypobromite Sodium Hypobromite Effervescence Specific Urease Phenol Red, 1% Acetic Acid or 2% Na2CO3 Faint Yellow Red Specific Urease Above Test + 1 ml of Urease + shake and wait for 10 minutes Intense Pink Colour Doremus Ureometer Uric Acid Benedicts Uric Acid test Benedicts Uric Acid Reagent + Na2CO3 Blue Colour Murexide Test Conc HNO3 + Heat Reddish Deposit Above Test+ dip a rod in dil NH3 and draw it through the deposit Reddish Violet Deposit + NaOH Bluish Violet Protein Heat Test Test Tube Heated Precipitate Sulphosalicylic Acid Test 25 % Sulphosalicylic Acid White Precipitate Nitirc Acid test Conc HNO3 White Ring Sugar Benedicts 5ml of Benedicts Qualitative Reagent + 8 drops of Urine Colour Change from Blue to Red Fehlings Fehlings reagent A + B Ketone Bodies Rothera Ammonium Sulphatre + Sodium Nitroprusside Purple Ring Gerhardts 10 % Ferric Chloride Purple Colour Iodoform Test Alkaline Iodine Beta OH butyric Acid Black reaction H2O2 Ferric and Ferrous Chloride Rose Colour Blood Benzidine Benzidine, Glacial Acetic Acid, H2O2 Deep Blue, Greenish Blue, Deep Geen Bile Salts Hays Sprinkle Sulphur (This is a PHYSICAL and NOT CHEMICAL TEST) Sulphur particles sink Petten-Koffers Sucrose Solution + H2SO4 Red Ring Oliver Acidified Peptone White Milky precipitate Bile Pigments Iodine Test Layer Tincture Iodine on Urine Green Ring Gmelin Layer Urine on Conc HNO3 Green, Blue or Violet Rings Fouchets 1% acetic Acid, BaCl2 Ammonium Sulphate + Fouchets Reagent Blue or Green Coles test Boil Urine + MgSO4 + BaCl2 + Absolute Alcohol + Potassium Chlorate Blue or Green Urobilinogen Ehrlichs Test p-dimethyl amino benzaldehyde and HCl Cherry Red Watsons Modification Ferrous hydroxide + Calorimetric Estimation Schlesinger Lugols iodine, Saturated Alcoholic Solution of Zinc Acetate or Zinc Chloride Greenish Flourescence Tips Ehrlichs Test is for Urobilinogen only !! Ehrlichs Reagent is for Urobilinogen as well as Porphobilinogen !!! Ehrlichs diazo reagent: Diazo reagent : Two solutions, one of sodium nitrite, the other of acidified sulfanilic acid, used in bringing about diazotization. This is reagent used in the Van de Bergh reaction used to estimate Bilirubin (Direct and Indirect) in Blood Ehrlichia: Small, often pleomorphic, coccoid to ellipsoidal organisms occurring intracytoplasmically in circulating lymphocytes. They are the aetiologic agents of tick-borne diseases of humans, dogs, cattle, sheep, goats, and horses. Ehrlichs anaemia: Aplastic anaemia Ehrlichs inner body: Heinz-Ehrlich body : A round oxyphil body found in the red blood cell in case of haemocytolysis due to a specific blood poison. Ehrlichs phenomenon: The difference between the amount of diphtheria toxin that will exactly neutralise one unit of antitoxin and that which, added to one unit of antitoxin, will leave one lethal dose free is greater than one lethal dose of toxin; i.e., it is necessary to add more than one lethal dose of toxin to a neutral mixture of toxin and antitoxin to make the mixture lethal (the basis of the L+ dose). Ehrlichs postulate: Side-chain theory : Ehrlich postulated that cells contained surface extensions or side chains (haptophores) that bind to the antigenic determinants of a toxin (toxophores); after a cell is stimulated, the haptophores are released into the circulation and become the antibodies. Ehrlich-Turk line: Seldom-used term for the vertical, thin deposition of material on the posterior surface of the cornea in uveitis. Ehrlichs triacid stain: A differential leukocytic stain comprised of saturated solutions of orange G, acid fuchsin, and methyl green. Fed up with Ehrlich.. Just One more Paul Ehrlich invented the Ziehl and Neelson Stain we use for staining AFB!!!!! Question. 47. Restriction fragment length polymophism is used for: A. Analysis of chromosome structure. B. DNA estimation. C. Synthesis of nucleic acid. D. Detecting proteins in a cell. Answer B. DNA estimation. Ref: Harper,25th,Pg-500 Harrison 15 Ed Table 65-9 Lippincott 2nd Edition Page 415 and Fihure 33.13 Quality: Spotter Status: Repeat QTDF: Harrison Discussion Methods Used for the Detection of Mutations Method Principle Type of Mutation Detected Cytogenic analysis Unique visual appearance of various chromosomes Numerical or structural abnormalities in chromosomes Fluorescent in situ hybridization (FISH) Hybridization to chromosomes with fluorescently labeled probes Numerical or structural abnormalities in chromosomes Southern blot Hybridization with genomic probe or cDNA probe after digestion of high molecular DNA Large deletion, insertion, rearrangement, expansions of triplet repeat, amplification Polymerase chain reaction (PCR) Amplification of DNA segment Expansion of triplet repeats, variable number of tandem repeats (VNTR), gene rearrangements, translocations; prepare DNA for other mutation methods Reverse transcriptase PCR (RT-PCR) Reverse transcription, amplification of DNA segment ? absence or reduction of mRNA transcription Analyzed expressed mRNA (cDNA) sequence; detect loss of expression DNA sequencing Direct sequencing of PCR products Sequencing of DNA segments cloned into plasmid vectors Point mutations, small deletions and insertions Single-strand conformational polymorphism (SSCP) PCR of DNA segment: Mutations result in conformational change and altered mobility Point mutations, small deletions and insertions Denaturing gradient gel electrophoresis (DGGE) PCR of DNA segment: Mutations result in conformational change and altered mobility Point mutations, small deletions and insertions RNAse cleavage Cleavage of mismatch between mutated and wild-type sequence Point mutations, small deletions and insertions Restriction fragment length polymorphism (RFLP) Detection of altered restriction pattern of genomic DNA (Southern blot) or PCR products Point mutations, small deletions and insertions Oligonucleotide specific hybridization (OSH) Hybridization of PCR products to wild-type or mutated oligonucleotides immobilized on chips or slides Point mutations, small deletions and insertions Microarrays Hybridization of PCR products to wild-type or mutated oligonucleotides Point mutations, small deletions and insertions Protein truncation test (PTT) Transcription/translation of cDNA isolated from tissue sample Mutations leading to premature truncations Explanation A. Analysis of chromosome structure is by Cytogenic analysis and Fluorescent in situ hybridization (FISH). B. DNA estimation is by Restriction fragment length polymorphism (RFLP) . C. Synthesis of nucleic acid is used in various other methods listed above. D. Detecting proteins in a cell is by Western Blot. Comments Strictly speaking, DNA is a chromosome and Chromosome is a DNA and so there are few who might tell that the answer is 1. But in case of any controversy, we always go by a Standard book and here Harrison is taken as a Standard. But remember that with RFLP we cannot see the Chromosome which is needed if we want to analyse the structure Tips Southern was the name of the person who invented Southern Blot, a process of determining the DNA structure. Then the process of determining RNA was called as Northern Blot and the process of determining proteins Western Blot ( DNA RNA Protein) What will be then Eastern Blot J Question. 48. Serum total lactate dehydrogenase level will NOT be raised in: A. Muscle crush injury. B. Stroke. C. Myocardial infrction. D. Hemolysis. Answer B. Stroke. Ref: Textbook of Medical Biochemistry 2nd Edition Chaterjee and Shinde Page 264 and 967 Textbook of Medical Biochemistry 4th Edition Chaterjee and Shinde Page 572 Quality: Spotter Status: Repeat QTDF: Chaterjee Discussion LDH or Lactate Dehydrogenase is an enzyme involved in Glycolysis and it converts Pyruvate to Lactate under anaerobic Conditions. In the presence of Oxygen Lactic Acid can be oxidized to Pyruvic Acid again. The characteristic features of this reaction are A. Reversible B. Same Enzyme C. Same Co Enzyme D. Oxidation Reduction LDH is found more in the following cells Cardiac muscle Skeletal muscle Liver Kidney RBC Normal Value of LDH is 60 to 250 IU/L (120 500 units/ml by Karmen spectroscopic method) It is elevated in Acute Myocardial infarction, Carcinomatosis, Acute Leukaemias, Granulocytic leukaemia, Pulmonary infarction, Renal Necrosis and Muscle Disease. Less pronounced LDH increases are seen in Inflammatory hepatic disorders Explanation A. Muscle crush injury is associated with elevated levels. B. Stroke is not associated with elevated levels. C. Myocardial infarction there is elevated LDH level The peak rise in Serum LDH is roughly proportional to theextent of the injury to the myocardial tissue The elevated levels may persist for more than a week after CPK and SGOT levels have returned to normal Serum LDH level > 1500 IU/L in AMI suggests grave prognosis D. Red blood cells are rich in LDH, hence in Hemolysis LDH levels are elevated. Particular care has to be taken while measuring LDH levels to ascertain that there is no hemolysis in the sample. Comments There are five Isoenzymes fo LDH. The active LDH Molecule is a Tetramer of molecular weight 130000 having 2 M and 2 H each having mol wt of 34,000 Daltons. Only the tetrameric forms are enzymatically active Isoenzyme Subunits Mol Formula Found in Starch Electrophoresis LDH 1 HHHH H4 Cardiac Moves far towards Anode, b/w Albumin and alpha-1-globulin LDH 2 HHHM H3M alpha-2-globulin LDH 3 HHMM H2M2 Beta region LDH 4 HMMM HM3 Fast gamma LDH 4 MMMM M4 Liver Behind gamma globulins Tips Read the other enzymes BIOSTATISTICS 7 Questions Recommended book for AIPG / AIIMS Exams A. RxPG Series - Biostatistics Buster - 1st Edition - Himanshu Tyagi - Jaypee Publishers Ref:s A. Park (obviously!!) B. Methods in Biostatistics for Medical Students and Research Workers - 6th Edition - B.K.Mahajan - Jaypee Publishers C. Methods of Biostatistics - Bhaskar Rao - PARAS Publishers D. High Yield Biostatistics The Basic Concepts in Biostatistics (given in all books) Disease Status Disease Status Test Results Diseased Not Diseased Total Positive a = true positive b = false positive a + b Negative c = false negative d = true negative c + d Total a + c b + d a + b + c + d Formulae Sensitivity = a/(a+c) x 100 Specificity = d/(b+d) x 100 Predictive Value of Positive Test = a/(a+b) x 100 Predictive Value of Negative Test = d/(c+d) x 100 Percentage of false positive = b/(b+d) x 100 Percentage of false negative = c/(a+c) x 100 Question. 49. Study this formula carefully: True positives X 100 True positives +False negatives This denotes: A. Sensitivity. B. Specificity. C. Positive Predctive value. D. Negative Predictive value. Answer A. Sensitivity. Ref: Park 16th Edition Page 110 Park 17th Edition Page 111 And all the books mentioned above give this Quality: Spotter Status: Repeat QTDF: Park Discussion See the formulae Explanation Self Explanatory Comments A definite question in All India !! Tips Get these formulae into your head Question. 50. For the calculation of positive predictive value of a screening test, the denominator is comprised of: A. True positives +False negatives. B. False positives + True negatives. C. True positives + False positives. D. True positives + True negatives. Answer C. True positives + False positives. Ref: Park 16th Edition Page 110 Park 17th Edition Page 111 And all the books mentioned above give this Quality: Spotter Status: Repeat QTDF: Park Discussion See the formulae Explanation Self Explanatory Comments Predictive value reflects the diagnostic power of the test. The predictive value of a positive test indicates the probability that a patient with a positive test result has in fact; the disease in question. The more prevalent a disease, in a given population, the more accurate will be the predictive value of a positive screening test. the predictive value of a positive test falls as disease prevalence declines. In positive predictive test the denominator is: True positive + False positive. In negative predictive test, the denominator is: False negative + True negative Tips Another definite question in All India !! Question. 51. The parameters of sensitivity and specificity are used for assessing: A. Criterion validity. B. Construct validity. C. Discriminant validity. D. Content validity. Answer A. Criterion validity. Ref: Park 16th Edition Page 110 Park 17th Edition Page 111 http://www.measurementexperts.org Quality: MSc Statistics / M.Com !!! Status: New QTDF: Some book for Statisticians. Who knows ;-) Discussion Validity is the degree to which an instrument measures what it is intended to measure. Note: reliability is a necessary but insufficient condition for validity. Reliability is a degree of consistency of a measure; the degree to which a test is free of random error. A test or measure that produces consistent results is said to have high reliability. Explanation A. Criterion validity is the degree to which a measure or test correlates with other measures or tests of the same construct assessed either concurrently or in the future; the ability of a test to predict a criterion. See also predictive validity. B. Construct validity is the degree to which an instrument accurately measures the construct of concern. Examples of construct validity include, but are not limited to, convergent and discriminant validity. C. Discriminant validity is a type of validity that is determined by hypothesizing and examining differential relations between a test and measures of similar or different constructs. It is the opposite of convergent validity and is also known as divergent validity. Convergent validity is a type of validity that is determined by hypothesizing and examining the overlap between two or more tests that presumably measure the same construct. D. Content validity is a method of establishing validity based on expert judgment that the content of the measure is consistent with what is to be measured. Comments Few more types of validity. (May be asked in future J) Concurrent validity - A method of determining validity as the correlation of the test with scores from known valid measures. Ecological validity - A type of validity that indicates the extent to which results will generalize to other settings. Face validity - The extent to which an instrument appears to be valid to those who are completing it. Individual patient monitoring validity - A validity index using a combination of useful endpoints to monitor individual patient response to care. Predictive validity - A type of criterion related validity in which a test is correlated with a criterion occurring at a later point in time. Tips As told else where, dont panic when you these questions that are not for an undergraduate, but specialist (this one is even not for a doctor). Even if some one has the question paper the previous day, he cannot answer these types of questions. Go to the next question Question. 52. A measure of location which divides the distribution in the ratio of 3:1 is: A. Median. B. First quartile. C. Third quartile. D. Mode. Answer C. Third quartile. Ref: Methods of Biostatistics by T.Bhaskar Rao (PARAS) Page 28 High Yield Biostatistics Page 9 Quality: Reader Status: New QTDF: High Yield Biostatistics Discussion The location of other points in the range can be measured by Percentiles of centiles, which are values in a series of observations, arranged in ascending order of magnitudes which divides the distribution into 100 equal parts. Median is 50th percentile. i.e. it will have 50% observations on either side, 10th percentile should have 10% observations to the left and 90% of the right. Percentiles are used to divide a distribution into convenient groups. Those in common use are: Quartile denotes division of the entire range of distribution into four equal parts, of equal probability by three equidistant points u First Quartile - will have distribution in the ratio = 1:3 (as 25% observations are to the left and 75% to the right) u Second Quartile - will have distribution in ratio = 2:2 (or 1:1 , as 50% observations are to the left and 50% to the right) u Third Quartile - will have distribution in the ratio= 3:1 (as 75% of observations are to left and 25% to the right) Quintiles: Four in number, divide the distribution into equal parts. u So 20th percentile or first quintile will have 20% observations falling on its left and 80% to its right. Deciles: Nine in number, divide the distribution into 10 equal parts. u First decile or 10th percentile will have 10% observations on its left and 90% to its right 5th decile will be same as median. Explanation A. Median is the middle value, when all the values are arranged either in ascending or descending order. B. First quartile will have distribution in the ratio = 1:3 (as 25% observations are to the left and 75% to the right). C. Third quartile will have distribution in the ratio= 3:1 (as 75% of observations are to left and 25% to the right). D. Mode is the most commonly occuring value. Comments Centiles are commonly used in Growth Charts (see the chapter Preventive Medicine is OG and Paediatrics) Tips Quartile has 4 parts and 3 points. Quintiles will have 5 parts and 4 points and so on. The number of points will be one less than the number of parts. The root in the terminology refers to the paRts and not the points. That means if some one asks you about how many points will be there in an Octile, dont jump to say 8. Octiles have 8 parts and 7 points Question. 53. Chi-square test is used to measure the degree of: A. Causal relationship between exposure and effect. B. Association between two variables. C. Correlation between two variables. D. Agreement between two observations. Answer B. Association between two variables. Ref: Mahajan Page Page 168,169 gives the ANSWER Also can be seen in Bhaskar Rao 115 Park 16th Edition Page 598 Park 17th Edition Page 616 Quality: Too Much Status: New and will be repeated !! QTDF: Mahajan Page 169 Discussion Chi -Square test involves calculation of a Quantity called Chi-Square (c2) from the greek letter Chi and pronounced as kye. It was developed by Karl Pearson and has got the following three common, but very important applications in medical statistics as a test of A. Propotion B. Association C. Goodness of fit The test of association between two events in binominal or multinominal samples is the most important application of the test in statistical methods. It measures the probability of association between two discrete attributes Explanation Self Explanatory Comments Fed up with Biostatistics.??!! Some thing else The Greek Alphabet Chi (c) is the name behind the terms Optic Chiasma (looks like a cross) and Chiasma in Chromosomes Tips Be ready with all the formulae in Statistics. Often you may get numerical Problems Question. 54 The P value of a randomised controlled trial comparing operation A [new procedure] & Operation B [Gold standard] is 0.04. From this, we conclude that: A. Type II error is small & we can accept the findings of the study. B. The probability of false negative conclusion that operation A is better than operation B, when in truth it is not, is 4%. C. The power of study to detect a difference between operation A&B is 96% . D. The probability of a false positive conclusion that operation a is better that operation B, when in truth it is not, is 4%. Answer D. The probability of a false positive conclusion that operation a is better that operation B, when in truth it is not, is 4%. Ref: Sabiston pretest Chapter 2...Q.22. Sabiston Pages 153 to 154 Also can be seen in Biostatistics Buster 129 Mahajan 122 High Yield Biostatistics Page 71 Bhaskar Rao 77 Quality: Thinker Status: New Question QTDF: Sabiston pretest Chapter 2...Q.22. the question and the choices are taken verbatim ..... Discussion The P Value or alpha is the probability that a false positive conclusion is selected when in truth it is not is called a Type I Error. The errorneous false negative conclusion is called as beta (Type II) Error. The probability of drawing a true positive conclusion when this is correct is called as the Power of study. By convention most studies use a 5 % risk of concluding that experimental therapy and the conventional therapy produce different clinical outcomes when in fact they do not (a false positive, Type I, or Alpha Error of 0.05) and run a 20 % risk of concluding that experimental and conventional therapy do not produce a clinical outcome when in fact they do (a false negative, Type II or beta Error or 0.2) The power of Study is then 1 to 0.20 or 80 % chance of finding a difference between two therapies and of finding a statistical difference Explanation Self Explanatory Comments I am sure you would not have expected an SPM Question from Surgery but this is the way with AIIMS people !!!! Sabiston Pretest gives few other rather important points, in a different perspective. A lot of question can be answered from that and it is a small book (and can be read in One day) as compared to Schwartz Pretest. Schwartz Pretest gained immense popularity as Surgery Questions and Choices of AIPG 2002 were asked Verbatim from that book Tips Type I Error Ilusion You see something that is not there Type II Error beta Blindness You dont see something that is there Mnemonic from Biostatistics Buster by Himanshu Tyagi Question. 55. For calculation of sample size for a prevalence study all of the following are necessary except: A. Prevalence of the disease in population. B. Power of the study. C. Significance level. D. Desired precision. Answer B. Power of the study. Ref: Methods of Biostatistics by Bhaskar Rao (PARAS) First Edition Section 9 - Calculation of Sample Size - Pages 102 - 105 Quality: For Statisticians Status: New QTDF: Bhaskar Rao Discussion Calculation of Sample size for a qualitative data Sample Size (N) = 4pq/L2 Where p = positive character q = 1-p L = allowable error in p (in %) usually 10 % or 20 % of p Eg : Death Rate of measles in children is found to be 10 %. What should be the size of sample needed to find death rates of measles Here p = 10 % q = 90 % L is 10 % of 10 % = 1 Hence N = 4 pg/L2 = 4 x 90 x 10 /1 x 1 = 3600 Calculation of Sample size for a quantitative data Sample Size (N) = {4pq/L2}x {x (1.1)/ghh} Where N = required Sample size 4 = Factor required to achive the 95 % level of confidence (Significance level comes here - Choice 3) p = Prevalence of Indicator (Choice 1) L = Margin of Error to be tolerated (Allowable error ie Precision - Choice 4 ) q = prevalence of Negative character x = design effect A. 1 = factor required to raise the sample size by 10 % for non -response g = propation of our population in the total population hh = Average house hold size Explanation A. Prevalence of the disease in population is needed. B. Power of the study is not needed. C. Significance level is needed. D. Desired precision is needed. 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This is the blowing muscle and D. This is the sucking Muscle ( May look mutually exclusive, but this is the fact) Tips Read the relevant Embryology and the Nerve Supply of these muscles 27. The cells belonging to the following type of epithelium are provided with extra reserve of cell membrane: A. Transitional B. Stratified squamous C. Stratified cuboidal. D. Stratified columnar. Answer: A (Transitional) Ref: Robbins Pathology 6th edn. Chapter 22 Page 997 Quality: Spotter Status: Reader QTDF: Gray, Robbins Discussion Urothelium lines much of the urinary tract, extending from the ends of the collecting ducts of the kidneys, through ureters and bladder to the proximal portion of the urethra. In males it covers the urethra as far as the ejaculatory ducts, then becomes intermittent, finally being replaced by pseudostratified epithelium in the membranous urethra. In females it also extends as far as the urogenital membrane. During development part of it is derived from mesoderm and part from ectoderm and endoderm. The epithelium appears to be 46 cells thick and lines organs which undergo considerable distension and contraction; it can, therefore, stretch greatly without losing its integrity. In stretching, the cells become flattened, without altering their positions relative to each other, since they are firmly connected by numerous desmosomes. On close inspection, many cells are seen to be attached to the basal lamina of the epithelium by slender basal processes and it has been proposed that perhaps all cells, even the most superficial, are attached to the base; thus this tissue could be viewed as a type of specialized pseudostratified epithelium, in which case it should be reclassified as a unilaminar epithelium The basally placed cells are cuboidal when relaxed, uninucleate (diploid) and basophilic with many ribosomes. More apically the cells progressively fuse to form larger, binucleate or uninucleate but polyploid cells. The surface cells are largest and may even be octoploid; their luminal surfaces are covered by a plasma membrane bearing plates of glycoprotein particles embedded in its lipid bilayer. These arrays stiffen the membrane so that, when the epithelium is in the relaxed state and the surface area of the cells is reduced, the glycoprotein-lipid plates are partially taken into the cytoplasm within vacuoles or diverticula, re-emerging on to the surface when its area increases once more through stretching These unusual membranes, together with the occluding junctions of the surface cells, form an effective barrier preventing urine from passing into the epithelium or beyond into the adjacent tissues. The urothelium, therefore, creates a protective lining to the urinary system which prevents its rather toxic contents from damaging surrounding structures. Normally, cell turnover is very slow, cell division being restricted to the basal layer, and infrequent. When damaged, however, the epithelium regenerates quite rapidly Explanation A. Transitional epithelium has an additional reserve of membrane B. Stratified squamous epithelia are multilayered tissues in which there is a constant formation, maturation and loss of cells. Formed mitotically in the most basal layers, their cells move more superficially, changing from a cuboidal or columnar shape to a more flattened form, and eventually being shed from the surface. These epithelia occur in sites exposed to mechanical stresses and provide for a constant protection of the underlying tissues against mechanical, microbial and chemical damage. C. Stratified cuboidalTwo or more layers of cuboidal cells are typical of the walls of the larger ducts of some exocrine glands, such as the pancreas and salivary glands and the ducts of sweat glands, presumably affording more strength than a single layer. These are not continually replaced by basal mitoses and there is no progression of form from base to surface, although they can repair themselves if damaged.. D. Stratified columnar. Two or more layers of columnar cells are typical of the walls of the larger ducts of some exocrine glands, such as the pancreas and salivary glands and the ducts of sweat glands, presumably affording more strength than a single layer. These are not continually replaced by basal mitoses and there is no progression of form from base to surface, although they can repair themselves if damaged. Comments There is one more transitional epithelium !!!! In the semicircular canals, where they border areas of sensory epithelium, the epithelial cells show a marked contrast with the unspecialized ductal cells, and here the underlying connective tissue layer is also thicker. In the maculae, the perimeter of the sensory epithelium is surrounded by a zone loosely termed transitional epithelium (quite unrelated to urinary epithelium which is sometimes given this name); around the periphery of the transitional epithelium and to some extent also interspersed with its cells is a zone of dark cells. Tips Histology is a High Yield area and another epithelium that is favourite to the examiners is Seminiferous epithelium Explanation A. Prevalence of the disease in population is needed. B. Power of the study is not needed. C. Significance level is needed. D. Desired precision is needed. 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