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"' *= X j y 0>@ @@$(()-)Document Master0񄋋D_-kD'|x%A\Pb` D_-kD'|x%A\Pb0߸pP0PP Document Master0񄋋D_-kD'|x%A\Pb '\P-kDlGáD*w-kDLD*w-kH!0߸pP0PP 0P0L 9P ('9@@@@@ @4@Zbr} @@@@@@!0N@m@@@@8@W@@@@#@@@@%@D@d@ @@@@@8@x@@`K7(F c  @ 9 @@ @?&B&9'< 3 <@@>OpP0PP @@ @?&B&9'< 3 <@@>Oc @P0PP Propofol is Di-Isopropylphenol It is prepared as an emulsion in 10% soyabean oil and 1.2% egg phosphatide and 2.25% glycerol Induction dose is 2-3 mg/kg Highly lipophilic 30%-40% of patients complain of pain/burning during injection Induction is rapid and recovery of consciousness after 4-7 minutes Post-anaesthetic performance of mental, manual and mechanical task is back to normal within 1-2 hours Suited for Day Care Surgery Safe for patients with Acute Intermittent Poyphyria It does not trigger malignant hyperthermia Hypotension is a common side effect Apnoea is common after induction and may last for 40-50 seconds Antioxidant Antiemetic Antipruritic Explanation A. Thiopentone sodium is an induction agent (contraindicated in AIP) and is not the drug for Day Care Anaesthesia. B. Ketamine is the anaesthesia of choice for patients in shock and produces delirium and is not the drug for Day Care Anaesthesia. C. Diazepam is a sedative and is not the drug for Day Care Anaesthesia. D. Propofol is the drug for Day Care Anaesthesia. Comments We have seen that Propofol is the anaesthesia of choice in Day Care Anaesthesia. The other agents that are used are: 1. Alfentanyl 2. Remifentanyl 3. Isoflurane 4. Sevoflurane 5. Desflurane 6. Methohexitone 7. Thiopentone 8. Etomidate Tips Similarly, there is a long list of what to use and what not to use in each specific conditions and the terrible fact is that those are asked often and you have no other way than to prepare them. Know the key details about all the anaesthetic agents. 4. The induction agent of choice in day care anaesthesia is: A. Sevoflurane B. Ketamine C. Propofol D. Methohexitone. Answer : C (Propofol) Ref: Clinical Anaesthesia 3rd edn Morgan, 173; KDT 4th edn, 352; Lee 12th edn, 417; SARP-SARP 6th edn, 108; PARAS-PARAS 4th edn, 46; Sure Success in PG Entrance 1st, 93 Quality: Spotter Status: Repeat from the same question paper QTDF: All books give this. Discussion You might have often heard about the theme couple in AIIMS and All India Exams. And this a classic example. Explanation A. Sevoflurane also can be used. B. Ketamine cannot be used. C. Propofol is the agent of choice. Please look at the discussion from the previous question. D. 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Ventilation with bag and mask is not done because with bag and mask ventilation, the air leak into stomach can raise intragastric pressure to more than 28 cm H2O (Critical pressure for aspiration) easily. An assistant applies pressure over cricoid (Sellicks manoeuvre) to prevent regurgitation and intubation is done with a small size endotracheal tube and cuff of endotracheal tube is inflated. If the intubation fails, spontaneous ventilation should be allowed to return and awake intubation performed. After surgery, the patient should remain intubated until airway reflexes and conciousness return. Explanation A. Sellick's manoeuvre is done B. Pre oxygenation is done for 4 to 5 minutes C. Suxamethonium is given D. Mechanical ventilation is not done for the fear of filling up stomach with gas and thereby potentiating vomiting Comments A new question in Anaesthesia out of our regular books we follow (SARP etc). Tips Questions like these are proof that solving AIPG and AIIMS question papers require in-depth knowledge of the subjects. 8. A 5-year-old boy suffering from Duchenne's muscular dystrophy has to undergo tendon-lengthening procedure. The most appropriate anaesthetic would be: A. Induction with intravenous thiopentone and N2O; and halothane for maintenance. B. Induction with intravenous propofol and N2O; and oxygen for maintenance. C. Induction with intravenous suxamethonium and N2O; and halothane for maintenance. D. Inhalation induction with inhalation halothane and N2O; oxygen for maintenance. Answer: B (Induction with intravenous propofol and N2O; and oxygen for maintenance) Ref: Miller 5th edn, 422; Nelson 15th edn Quality: Thinker Status: Repeat from AIIMS QTDF: Miller Discussion Anaesthesia in a case of neuromuscular disease: In neuromuscular diseases, anaesthesia of choice is peripheral nerve blocks, local and central neuraxial block (below T9). If GA is to be given, then it should be contemplated with total intravenous anaesthesia (propofol + fentanyl) and maintained on oxygen, nitrous oxide and opioid. Relaxation, if needed, is achieved by inhalational agents; and if sufficient relaxation is not achieved by them, non-depolarising relaxants like atracurium should be given and dose is adjusted according to neuromuscular monitoring response. Halothane causes malignant hyperpyrexia and should not be used succinylcholine causes intractable cardiac arrest in a child with Duchenne's muscular dystrophy. Another view is that, for a normal patient, in any surgery involving muscle lengthening/shortening, the dictum is not using Ether/Halothane which can alter the tension of the muscle and use N2O which has no effect on muscles.... Explanation A. Halothane cannot be used B. This is the correct answer C. Both succinyl choline as well as halothane cannot be used and this seems to be a preposterous choice !! D. Halothane cannot be used Comments Malignant Hyperthermia occurs in individuals with: an inherited abnormality of skeletal muscle sarcoplasmic reticulum that causes a rapid increase in intracellular calcium levels in response to halothane and other inhalational anaesthetics or to succinylcholine, elevated temperature, increased muscle metabolism, rigidity, rhabdomyolysis, acidosis, and cardiovascular instability develops rapidly. This condition is often fatal. Earliest signMasseter muscle rigidity Other signsTachycardia, hypercarbia Triggering Drugs Protective Drugs Enflurane, Isoflurane, Nitrous oxide Desflurane, Sevoflurane, Droperidol Methoxyflurane Local anaesthetics Succinylcholine Etomidate Pancuronium Propofol Thiopentone Ketamine 1. To be treated immediately 2. Cessation of anaesthesia and 3. Intravenous administration of dantrolene sodium: a. The recommended dose of dantrolene is 1 to 2.5 mg/kg of body weight given intravenously every 6 h for at least 24 to 48 huntil oral dantrolene can be administered, if needed. b. Dantrolene at similar doses is indicated in the: Neuroleptic malignant syndrome. In drug-induced hyperthermia and  May even be useful in the hyperthermia of thyrotoxicosis. 4. Procainamide should also be administered to patients with malignant hyperthermia because of the likelihood of ventricular fibrillation in this syndrome. The neuroleptic malignant syndrome can occur with phenothiazines and other drugs such as haloperidol and is Characterised by: Muscle rigidity, Autonomic dysregulation, and Hyperthermia. This disorder appears to be caused by the: Inhibition of central dopamine receptors in the hypothalamus, Results in increased heat generation, and Decreased heat dissipation. Thyrotoxicosis and pheochromocytoma can also cause increased thermogenesis. The neuroleptic malignant syndrome may also be treated with: Bromocriptine, Levodopa, Amantadine, or Nifedipine or By induction of muscle paralysis with curare and pancuronium. Tricyclic antidepressant overdose may be treated with physostigmine. Tips A repeat question from AIIMS. May be you will get this in future too. Read the basics about the anaesthesia in certain disease conditions and physiological states. Drugs causing malignant hyperthermia are SCHEME Succinylcholine Cyclopropane Halothane Ether Methoxyflurane 9. In all of the following conditions neuraxial blockade is absolutely contraindicated, except: A. Patient refusal. B. Coagulopathy. C. Severe hypovolemia. D. Pre-existing neurological deficits. Answer: D (Pre-existing neurological deficits) Ref: Clinical Anaesthesia 3rd edn Morgan 262; Lee 12th edn, 369; PARAS-PARAS 4th edn, 66 Quality: Reader Status: New Question QTDF: Morgan Discussion Neuraxial block means spinal and epidural anaesthesia as well as caudal blocks and here the agent acts at the level of the nerve root. There are a few absolute and few relative contraindications for spinal and epidural anaesthesia. The absolute contraindications are: 1. Infection at the site of injection 2. Patient refusal 3. Coagulopathy 4. Severe hypovolaemia 5. 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Severe aortic stenosis 7. Severe mitral stenosis The relative contraindications are: 1. Sepsis 2. Uncooperative patient 3. Pre-existing neurological deficit 4. Stenotic heart valves 5. Severe spinal deformity Explanation A. Patient refusal is an absolute contraindication. B. Coagulopathy is an absolute contraindication C. Severe hypovolaemia is an absolute contraindication. D. Pre-existing neurological deficits is a relative contraindication. Comments If spinal is to be given in patient already having neuropathies, it is mandatory to mention all the deficits in pre-anaesthetic sheet to avoid any litigation. Tips Go through other details of spinal anaesthesia like the first nerves to be blocked, order of blocking, most common complication, etc. 10. Interscalene approach to brachial plexus block does not provide optimal surgical anaesthesia in the area of distribution of which of the following nerve: A. Musculocutaneous. B. Ulnar. C. Radial. D. Median. Answer: B (Ulnar) Ref: Clinical Anaesthesia 3rd edn. Morgan 288; Miller 3rd edn, 1408; Lee 12th edn, 619 Quality: Reader Status: New Question QTDF: Morgan Discussion Interscalene approach to brachial plexus is via the interscalene groove. In this approach, since the anaesthetic agents are infiltrated from above, ulnar nerve, being situated at a lower position, is not adequately covered. Explanation A. Area of distribution of musculocutaneous nerve is adequately anaesthetised. B. Area of distribution of ulnar is not adequately anaesthetised. C. Area of distribution of radial is adequately anaesthetised. D. Area of distribution of median is adequately anaesthetised. Comments New question directly out of Morgan. This question again emphasises the fact that you have to be thorough with the anatomy of head and neck and thorax and upper limb when you are appearing for MCQ exam. And let us see a few more facts. A. Interscalene approach blocks the upper roots more and is thus suited for the procedures on shoulder, arm. B. Axillary approach blocks the lower roots more and is thus suited for the procedures on forearm, hand. C. Supraclavicular and infraclavicular approaches are more evenly distributed. Tips A practical guideline while giving brachial plexus block is to check the analgesia in all segments before proceding to the surgery. There are cases (for example while operating for fracture both bone forearm) when the surgeon just checked the anaesthesia in an area (with the forceps) operated that and when he finished one bone and came to the next incision(well every one present in the theatre will not like to happen once more). 11. The blood gas parameters: pH 7.58, PCO2 23 mmHg PO2, 300 mmHg and oxygen saturation 60% are most consistent with: A. Carbon monoxide poisoning. B. Ventilatory malfunction. C. Voluntary hyperventilation. D. Methyl alcohol poisoning. Answer: B (Ventilatory malfunction) Ref: Clinical Anaesthesia 3rd edn Morgan 652. Table 30-3 Quality: Thinker Status: New QTDF: Morgan Discussion The blood pH of 7.58 is alkalosis and the PCO2 of 23 mmHg points out to CO2 washout. Hence, this could be only respiratory alkalosis. Explanation A. Carbon monoxide poisoning will produce acidosis. B. Ventilatory malfunction can produce any of the metabolic derangement. C. Voluntary hyperventilation will produce respiratory alkalosis but the oxygen saturation will not be 60%. D. Methyl alcohol poisoning will produce metabolic acidosis. By exclusion, we come to the answer B, i.e. ventilatory malfunction. Comments To find out the metabolic/respiratory abnormality, look at the pH. If it is more than 7.4, it is alkalosis; and if it is less than 7.4, it is acidosis. Then look at the CO2 or HCO3 If there is acidosis and increased CO2 or HCO3, it is respiratory acidosis. If there is acidosis and decreased CO2 or HCO3, it is metabolic acidosis. If there is alkalosis and increased CO2 or HCO3, it is metabolic alkalosis. If there is alkalosis and decreased CO2 or HCO3, it is respiratory alkalosis. Tips Acid-base and electrolyte balance have to be studied thoroughly. XThis is a theme couple. Theme couple means 2 questions are asked from the same topic in the same exam. Sometimes the 2 may be even the same question, and sometimes there will be a slight twist (or a trap) between the two. Tips Be at look out for theme couples in AIPG and AIIMS question papers. While answering theme couples, you will get: 8 marks when you get both right; 2 when you get both wrong; 3 if you get one right and the other wrong; and 0 when you dont attempt. If you know the answer, you can get 8 marks, but if there are doubts about the answer in the exam hallI will mark two different answers what will you do? 5. Induction agent that may cause adrenal cortex suppression is: A. Ketamine B. Etomidate C. Propofol D. Thiopentone. Answer: B (Etomidate) Ref: Harrison 15th edn 328: ACTH; Harrison 15th edn Table 71-2; Lee 12th edn, 185; KDT 4th edn, 353; SARP-SARP 6th edn, 110; PARAS-PARAS 4th edn, 46; Sure Success in PG Entrance 1st edn, 94; Davidson, at the Endocrinology topic Quality: Spotter Status: Repeat QTDF: All books give this. Discussion Etomidate is a short-acting hypnotic, which appears to have gamma-aminobutyric acid (GABA)-like effects. Unlike the barbiturates, etomidate reduces subcortical inhibition at the onset of hypnosis while inducing neocortical sleep. Studies in animals suggest that a part of the action of etomidate consists of a depression of the activity and reactivity of the brainstem reticular formation. Etomidate is a non-barbituate intravenous induction agent and it inhibits 11-beta hydroxylase. It also causes vitamin C deficiency and has a very high incidence of myoclonus and thrombophlebitis. It is contraindicated in pregnancy. Explanation A. Ketamine increases all pressures and is contraindicated in pregnancy. B. Etomidate is the answer. C. Propofol has already been dealt with and is associated with pain and myotonic effects. D. Thiopentone exacerbates AIP in susceptible patients. Comments Etomidate does not cause significant cardiovascular or respiratory depression, but may cause a brief period of apnea. Also, it does not appear to elevate plasma histamine or cause histamine release when administered in recommended doses. The decrease in cerebral blood flow produced by etomidate is approximately the same as that produced by thiopental and methohexital; this reduction appears to be uniform in the absence of intracranial tumors. Etomidate slightly lowers intracranial pressure and it usually causes a moderate decrease in intraocular pressure. Also, etomidate [at induction doses of 0.3 mg per kg of body weight (mg/kg)] has been reported to reduce plasma cortisol concentrations; this effect persists for 6 to 8 hours and appears to be unresponsive to adrenocorticotropic hormone (ACTH). Tips Other drugs causing addisonian-like syndrome include Busulfan and ketoconazole. 6. At the end of a balanced anaesthesia technique with non-depolarizing muscle relaxant, a patient recovered spontaneously from the effect of muscle relaxant without any reversal. Which is the most probable relaxant the patient had received? A. Pancuronium. B. Gallamine. C. Atracurium. D. Vecuronium. Answer: C (Atracurium) Ref: Clinical Anaesthesia 3rd edn, Morgan 191; KDT 4th edn, 154; Lee 12th, 213; SARP-SARP 6th edn, 122; PARAS-PARAS 4th edn, 58; Sure Success in PG Entrance 1st edn, 102 Quality: Spotter Status: Repeat QTDF: All books (except Tripathi) give this. Tripathi says vecuronium !!! Discussion Balanced anaesthesia (introduced by Lundy) is: 1. Thiopentone for induction 2. N2O for amnesia 3. Opioid for analgesia 4. Curare for muscle relaxation Atracurium is: Benzylisoquinoliniums Undergoes Hoffman's degradation at body temperature Stored at 4oC Relaxant of choice in patients with hepatic or renal dysfunction Suitable for patients with atypical cholinesterase, organophosphorus poisoning and in myasthenia gravis Contraindicated in asthma Side effect is histamine release Metabolite is laudanosine which is a CNS derivative Explanation Do we need an explanation !! A. Pancuronium is not used in liver failure. B. Gallamine is totally excreted by kidney. C. Atracurium undergoes Hoffmans degradation. D. Vecuronium is safe in liver failure and has no cardiovascular side effects and does not release histamine. Comments Atracurium undergoes Hoffman's degradation (95%) and also ester hydrolysis (5%) in plasma. Tips Xenobiotics can hurl a question at you in unexpected places. Be prepared !!! 7. During rapid sequence induction of anaesthesia: A. Selicks manoeuvre is not required. B. Pre-oxygenation is mandatory. C. Suxamethonium is contraindicated. D. Patient is mechanically ventilated before end-tracheal incubation. 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Adobe Compatibility CMSPageMaker 5.0 CMYKThis is a theme couple. Theme couple means 2 questions are asked from the same topic in the same exam. Sometimes the 2 may be even the same question, and sometimes there will be a slight twist (or a trap) between the two. Tips Be at look out for theme couples in AIPG and AIIMS question papers. While answering theme couples, you will get: 8 marks when you get both right; 2 when you get both wrong; 3 if you get one right and the other wrong; and 0 when you dont attempt. If you know the answer, you can get 8 marks, but if there are doubts about the answer in the exam hallI will mark two different answers what will you do? 5. Induction agent that may cause adrenal cortex suppression is: A. Ketamine B. Etomidate C. Propofol D. Thiopentone. Answer: B (Etomidate) Ref: Harrison 15th edn 328: ACTH; Harrison 15th edn Table 71-2; Lee 12th edn, 185; KDT 4th edn, 353; SARP-SARP 6th edn, 110; PARAS-PARAS 4th edn, 46; Sure Success in PG Entrance 1st edn, 94; Davidson, at the Endocrinology topic Quality: Spotter Status: Repeat QTDF: All books give this. Discussion Etomidate is a short-acting hypnotic, which appears to have gamma-aminobutyric acid (GABA)-like effects. Unlike the barbiturates, etomidate reduces subcortical inhibition at the onset of hypnosis while inducing neocortical sleep. Studies in animals suggest that a part of the action of etomidate consists of a depression of the activity and reactivity of the brainstem reticular formation. Etomidate is a non-barbituate intravenous induction agent and it inhibits 11-beta hydroxylase. It also causes vitamin C deficiency and has a very high incidence of myoclonus and thrombophlebitis. It is contraindicated in pregnancy. Explanation A. Ketamine increases all pressures and is contraindicated in pregnancy. B. Etomidate is the answer. C. Propofol has already been dealt with and is associated with pain and myotonic effects. D. Thiopentone exacerbates AIP in susceptible patients. Comments Etomidate does not cause significant cardiovascular or respiratory depression, but may cause a brief period of apnea. Also, it does not appear to elevate plasma histamine or cause histamine release when administered in recommended doses. The decrease in cerebral blood flow produced by etomidate is approximately the same as that produced by thiopental and methohexital; this reduction appears to be uniform in the absence of intracranial tumors. Etomidate slightly lowers intracranial pressure and it usually causes a moderate decrease in intraocular pressure. Also, etomidate [at induction doses of 0.3 mg per kg of body weight (mg/kg)] has been reported to reduce plasma cortisol concentrations; this effect persists for 6 to 8 hours and appears to be unresponsive to adrenocorticotropic hormone (ACTH). Tips Other drugs causing addisonian-like syndrome include Busulfan and ketoconazole. 6. At the end of a balanced anaesthesia technique with non-depolarizing muscle relaxant, a patient recovered spontaneously from the effect of muscle relaxant without any reversal. Which is the most probable relaxant the patient had received? A. Pancuronium. B. Gallamine. C. Atracurium. D. Vecuronium. Answer: C (Atracurium) Ref: Clinical Anaesthesia 3rd edn, Morgan 191; KDT 4th edn, 154; Lee 12th, 213; SARP-SARP 6th edn, 122; PARAS-PARAS 4th edn, 58; Sure Success in PG Entrance 1st edn, 102 Quality: Spotter Status: Repeat QTDF: All books (except Tripathi) give this. Tripathi says vecuronium !!! Discussion Balanced anaesthesia (introduced by Lundy) is: 1. Thiopentone for induction 2. N2O for amnesia 3. Opiod for analgesia 4. Curare for muscle relaxation Atracurium is: Benzylisoquinoliniums Undergoes Hoffman's degradation at body temperature Stored at 4oC Relaxant of choice in patients with hepatic or renal dysfunction Suitable for patients with atypical cholinesterase, organophosphorus poisoning and in myasthenia gravis Contraindicated in asthma Side effect is histamine release Metabolite is laudanosine which is a CNS derivative Explanation Do we need an explanation !! A. Pancuronium is not used in liver failure. B. Gallamine is totally excreted by kidney. C. Atracurium undergoes Hoffmans degradation. D. Vecuronium is safe in liver failure and has no cardiovascular side effects and does not release histamine. Comments Atracurium undergoes Hoffman's degradation (95%) and also ester hydrolysis (5%) in plasma. Tips Xenobiotics can hurl a question at you in unexpected places. Be prepared !!! 7. During rapid sequence induction of anaesthesia: A. Selicks manoeuvre is not required. B. Pre-oxygenation is mandatory. C. Suxamethonium is contraindicated. D. Patient is mechanically ventilated before end-tracheal incubation. Answer: B (Pre-oxygenation is mandatory) Ref: Miller 5th edn, 434; Lees Synopsis of Anaesthesia 12th, 388 ,@ l ,@ l ,@ l ,@ l ,@ l ZGd ZGdZGdZGdZGd(ZGdZGd ZGd/ZGdZGdZGdZGdZGdZGd"ZGdZGdZGdZGdZGd5ZGdZGd ZGdZGdZGdZGdDZGdZGdoZGdZGdZGdZGd"ZGdZGd5ZGd ZGdZGdZGdZGd+ZGdZGdZGd*ZGdZGdZGd-ZGdZGdZGdpZGd ZGdgZGdZGdOZGd8ZGd$ZGdZGdZGdZGd"ZGdZGdEZGd ZGd ZGdZGd(ZGdZGdZGdZGdZGdZGd ZGd ZGdWZGdZGdZGd ZGdZGdZGdZGd+ZGdZGdZGdZGdwZGd ZGdMZGdZGdxZGdZGd,ZGdZGd"ZGdZGd)ZGdZGdZGdZGd.ZGdZGd"ZGdZGd4ZGdZGdZGdZGdZGdZGd+ZGdZGdZGdZGdZGdZGdZGdZGdZGdZGdZGdZGdZGd ZGd0ZGdwZGdZGdZGd ZGd{ZGddZGd]ZGdZGd%ZGd ZGdZGdZGdZGdZGdZGdhZGdZGdZGd ZGd3ZGdZGdZGd!ZGdZGdZGdZGdRZGd*ZGd(ZGd22Gd$ZGd22GdZGd22GdwZGd<GdZGd<GdZGd<GdZGd<GdZGdZGdnZGdZGdZGd<GdZGd<GdZGd<GdZGd<GdZGd<GdZGd<GdZGdZGd-ZGd<GdZGd<GdCZGd<GdZGd<Gd+ZGd<GdZGd<GdZGd<GdZGd<GdLZGdZGd@ZGd<GdZGd<GdZGd<GdZGd<Gd ZGd<GdZGd<GdZGd<GdZGd<GdZGd<GdZGd<Gd?ZGd<GdZGd<GdEZGdZGdFZGdZGdZGd6Quality: Reader Status: New Question QTDF: Miller, Lee Discussion In rapid sequence induction, induction is done after pre-oxygenation for 4-5 minutes, induction agent (thiopentone) is given, followed immediately by succinylcholine (suxamethonium). Ventilation with bag and mask is not done because with bag and mask ventilation, the air leak into stomach can raise intragastric pressure to more than 28 cm H2O (Critical pressure for aspiration) easily. An assistant applies pressure over cricoid (Sellicks manoeuvre) to prevent regurgitation and intubation is done with a small size endotracheal tube and cuff of endotracheal tube is inflated. If the intubation fails, spontaneous ventilation should be allowed to return and awake intubation performed. After surgery, the patient should remain intubated until airway reflexes and conciousness return. Explanation A. Sellick's manoeuvre is done B. Pre oxygenation is done for 4 to 5 minutes C. Suxamethonium is given D. Mechanical ventilation is not done for the fear of filling up stomach with gas and thereby potentiating vomiting Comments A new question in Anaesthesia out of our regular books we follow (SARP etc). Tips Questions like these are proof that solving AIPG and AIIMS question papers require in-depth knowledge of the subjects. 8. A 5-year-old boy suffering from Duchenne's muscular dystrophy has to undergo tendon-lengthening procedure. The most appropriate anaesthetic would be: A. Induction with intravenous thiopentone and N2O; and halothane for maintenance. B. Induction with intravenous propofol and N2O; and oxygen for maintenance. C. Induction with intravenous suxamethonium and N2O; and halothane for maintenance. D. Inhalation induction with inhalation halothane and N2O; oxygen for maintenance. Answer: B (Induction with intravenous propofol and N2O; and oxygen for maintenance) Ref: Miller 5th edn, 422; Nelson 15th edn Quality: Thinker Status: Repeat from AIIMS QTDF: Miller Discussion Anaesthesia in a case of neuromuscular disease: In neuromuscular diseases, anaesthesia of choice is peripheral nerve blocks, local and central neuraxial block (below T9). If GA is to be given, then it should be contemplated with total intravenous anaesthesia (propofol + fentanyl) and maintained on oxygen, nitrous oxide and opioid. Relaxation, if needed ,is achieved by inhalational agents; and if sufficient relaxation is not achieved by them, non-depolarising relaxants like atracurium should be given and dose is adjusted according to neuromuscular monitoring response. Halothane causes malignant hyperpyrexia and should not be used succinylcholine causes intractable cardiac arrest in a child with Duchenne's muscular dystrophy. Another view is that, for a normal patient, in any surgery involving muscle lengthening/shortening, the dictum is not using Ether/Halothane which can alter the tension of the muscle and use N2O which has no effect on muscles.... Explanation A. Halothane cannot be used B. This is the correct answer C. Both Succinyl Choline as well as Halothane cannot be used and this seems to be a preposterous choice !! D. Halothane cannot be used Comments Malignant Hyperthermia occurs in individuals with: an inherited abnormality of skeletal muscle sarcoplasmic reticulum that causes a rapid increase in intracellular calcium levels in response to halothane and other inhalational anaesthetics or to succinylcholine, elevated temperature, increased muscle metabolism, rigidity, rhabdomyolysis, acidosis, and cardiovascular instability develops rapidly. This condition is often fatal. Earliest signMasseter muscle rigidity Other signsTachycardia, hypercarbia Triggering Drugs Protective Drugs Enflurane, Isoflurane, Nitrous oxide Desflurane, Sevoflurane, Droperidol Methoxyflurane Local anaesthetics Succinylcholine Etomidate Pancuronium Propofol Thiopentone Ketamine 1. To be treated immediately 2. Cessation of anaesthesia and 3. Intravenous administration of dantrolene sodium: a. The recommended dose of dantrolene is 1 to 2.5 mg/kg of body weight given intravenously every 6 h for at least 24 to 48 huntil oral dantrolene can be administered, if needed. b. Dantrolene at similar doses is indicated in the: Neuroleptic malignant syndrome. In drug-induced hyperthermia and  May even be useful in the Hyperthermia of thyrotoxicosis. 4. Procainamide should also be administered to patients with malignant hyperthermia because of the likelihood of ventricular fibrillation in this syndrome. The neuroleptic malignant syndrome can occur with phenothiazines and other drugs such as haloperidol and is Characterised by: Muscle rigidity, Autonomic dysregulation, and Hyperthermia. This disorder appears to be caused by the: Inhibition of central dopamine receptors in the hypothalamus, Results in increased heat generation, and Decreased heat dissipation. Thyrotoxicosis and pheochromocytoma can also cause increased thermogenesis. The neuroleptic malignant syndrome may also be treated with: Bromocriptine, Levodopa, Amantadine, or Nifedipine or By induction of muscle paralysis with curare and pancuronium. Tricyclic antidepressant overdose may be treated with physostigmine. Tips A repeat question from AIIMS. May be you will get this in future too Read the basics about the anaesthesia in certain disease conditions and physiological states. Drugs causing malignant hyperthermia are SCHEME Succinylcholine Cyclopropane Halothane Ether Methoxyflurane 9. In all of the following conditions neuraxial blockade is absolutely contraindicated, except: A. Patient refusal. B. Coagulopathy. C. Severe hypovolemia. D. Pre-existing neurological deficits. Answer: D (Pre-existing neurological deficits) Ref: Clinical Anaesthesia 3rd edn Morgan 262; Lee 12th edn, 369; PARAS-PARAS 4th edn, 66 Quality: Reader Status: New Question QTDF: Morgan Discussion Neuraxial block means spinal and epidural anaesthesia as well as caudal blocks and here the agent acts at the level of the nerve root. There are a few absolute and few relative contraindiations for spinal and epidural anaesthesia. The absolute contraindications are: 1. Infection at the site of injection 2. Patient refusal 3. Coagulopathy 4. 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Ventilation with bag and mask is not done because with bag and mask ventilation, the air leak into stomach can raise intragastric pressure to more than 28 cm H2O (Critical pressure for aspiration) easily. An assistant applies pressure over cricoid (Sellicks manoeuvre) to prevent regurgitation and intubation is done with a small size endotracheal tube and cuff of endotracheal tube is inflated. If the intubation fails, spontaneous ventilation should be allowed to return and awake intubation performed. After surgery, the patient should remain intubated until airway reflexes and conciousness return. Explanation A. Sellick's manoeuvre is done B. Pre oxygenation is done for 4 to 5 minutes C. Suxamethonium is given D. Mechanical ventilation is not done for the fear of filling up stomach with gas and thereby potentiating vomiting Comments A new question in Anaesthesia out of our regular books we follow (SARP etc). Tips Questions like these are proof that solving AIPG and AIIMS question papers require in-depth knowledge of the subjects. 8. A 5-year-old boy suffering from Duchenne's muscular dystrophy has to undergo tendon-lengthening procedure. The most appropriate anaesthetic would be: A. Induction with intravenous thiopentone and N2O; and halothane for maintenance. B. Induction with intravenous propofol and N2O; and oxygen for maintenance. C. Induction with intravenous suxamethonium and N2O; and halothane for maintenance. D. Inhalation induction with inhalation halothane and N2O; oxygen for maintenance. Answer: B (Induction with intravenous propofol and N2O; and oxygen for maintenance) Ref: Miller 5th edn, 422; Nelson 15th edn Quality: Thinker Status: Repeat from AIIMS QTDF: Miller Discussion Anaesthesia in a case of neuromuscular disease: In neuromuscular diseases, anaesthesia of choice is peripheral nerve blocks, local and central neuraxial block (below T9). If GA is to be given, then it should be contemplated with total intravenous anaesthesia (propofol + fentanyl) and maintained on oxygen, nitrous oxide and opioid. Relaxation, if needed, is achieved by inhalational agents; and if sufficient relaxation is not achieved by them, non-depolarising relaxants like atracurium should be given and dose is adjusted according to neuromuscular monitoring response. Halothane causes malignant hyperpyrexia and should not be used succinylcholine causes intractable cardiac arrest in a child with Duchenne's muscular dystrophy. Another view is that, for a normal patient, in any surgery involving muscle lengthening/shortening, the dictum is not using Ether/Halothane which can alter the tension of the muscle and use N2O which has no effect on muscles.... Explanation A. Halothane cannot be used B. This is the correct answer C. Both succinyl choline as well as halothane cannot be used and this seems to be a preposterous choice !! D. Halothane cannot be used Comments Malignant Hyperthermia occurs in individuals with: an inherited abnormality of skeletal muscle sarcoplasmic reticulum that causes a rapid increase in intracellular calcium levels in response to halothane and other inhalational anaesthetics or to succinylcholine, elevated temperature, increased muscle metabolism, rigidity, rhabdomyolysis, acidosis, and cardiovascular instability develops rapidly. This condition is often fatal. Earliest signMasseter muscle rigidity Other signsTachycardia, hypercarbia Triggering Drugs Protective Drugs Enflurane, Isoflurane, Nitrous oxide Desflurane, Sevoflurane, Droperidol Methoxyflurane Local anaesthetics Succinylcholine Etomidate Pancuronium Propofol Thiopentone Ketamine 1. To be treated immediately 2. Cessation of anaesthesia and 3. Intravenous administration of dantrolene sodium: a. The recommended dose of dantrolene is 1 to 2.5 mg/kg of body weight given intravenously every 6 h for at least 24 to 48 huntil oral dantrolene can be administered, if needed. b. Dantrolene at similar doses is indicated in the: Neuroleptic malignant syndrome. In drug-induced hyperthermia and  May even be useful in the hyperthermia of thyrotoxicosis. 4. Procainamide should also be administered to patients with malignant hyperthermia because of the likelihood of ventricular fibrillation in this syndrome. The neuroleptic malignant syndrome can occur with phenothiazines and other drugs such as haloperidol and is Characterised by: Muscle rigidity, Autonomic dysregulation, and Hyperthermia. This disorder appears to be caused by the: Inhibition of central dopamine receptors in the hypothalamus, Results in increased heat generation, and Decreased heat dissipation. Thyrotoxicosis and pheochromocytoma can also cause increased thermogenesis. The neuroleptic malignant syndrome may also be treated with: Bromocriptine, Levodopa, Amantadine, or Nifedipine or By induction of muscle paralysis with curare and pancuronium. Tricyclic antidepressant overdose may be treated with physostigmine. Tips A repeat question from AIIMS. May be you will get this in future too Read the basics about the anaesthesia in certain disease conditions and physiological states. Drugs causing malignant hyperthermia are SCHEME Succinylcholine Cyclopropane Halothane Ether Methoxyflurane 9. In all of the following conditions neuraxial blockade is absolutely contraindicated, except: A. Patient refusal. B. Coagulopathy. C. Severe hypovolemia. D. Pre-existing neurological deficits. Answer: D (Pre-existing neurological deficits) Ref: Clinical Anaesthesia 3rd edn Morgan 262; Lee 12th edn, 369; PARAS-PARAS 4th edn, 66 Quality: Reader Status: New Question QTDF: Morgan Discussion Neuraxial block means spinal and epidural anaesthesia as well as caudal blocks and here the agent acts at the level of the nerve root. There are a few absolute and few relative contraindiations for spinal and epidural anaesthesia. The absolute contraindications are: 1. Infection at the site of injection 2. Patient refusal 3. Coagulopathy 4. 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They stabilize unfolded or partially folded intermediates, allowing them to fold properly and prevent inappropriate interactions. Few substances that can be called as chaperones include A. Calreticulin B. HSP 90A (Heat Shock Proteins) C. Synuclein alpha D. Lectin mannose binding 1 5. DNA fragmentation factor 45 6. Tubulin specific chaperone C 7. Arylhydrocarbon-interacting receptor protein-like 1 8. Tubulin specific chaperone D 9. Unactive progesterone receptor 23KD (Yeah, That is its name it is not printing mistake Explanation A. Protein synthesis is a big process that involves a whole lot of enzymes. B. Protein degradation is by the digestive enzymes. C. Protein denaturation is usually by heat, organic solvents, mechanical mixing, strong acids or bases, detergents and ions of heavy metals such as lead and mercury. D. Protein folding is by Chaperones. Comments Few more points about Chaperones A. Present in many species B. Few are induced by conditions which cause unfolding of newly synthesized proteins C. Bind predominantly to Hydrophobic regions D. Act as Editing Mechanisms or Quality: control 5. Most have ATPase activity 6. Found in a. Cytosol b. Mitochondria c. Lumen of Endoplasmic Reticulum Tips Read the enzymes involved in Human as well as Bacterial Protein Synthesis with relevance to Pharmacology ( Anti microbial and chemotherapeutic agent) Question. 39. Which of the following is present intracellularly in muscle cells: A. Insulin. B. Corticosteroid. C. Epinephrine. D. Glucagon. Answer Since all are present inside the cell, We read the question as for which of the following, the receptor is present inside the cell and then the answer will be B. Corticosteroid. Ref: KDT 4th Edition Page 240,241 KDT 5th Edition Page 214 Ganong Quality: Spotter with a small mistake Status: Repeat QTDF: Ganong Discussion Receptors for most of the hormones are in the cell membrance u Act by camp Adrenaline, Glucagon, TSH, FSH, LH, PTH, ACTH, some hypothalamic Releasing factors u Act by IP3/DAG Vasopressin Oxytocin u Act by Enzyme Activation Tyrosine Linase - Insulin Receptors of Few are inside the cell u In cytoplasm Steroids other than Estrogen u In Nucleus Estrogen (Refer Ganong Chaper 1 and the MCQs given at the back of the book in Chapter 1) Thyroid hormones T3, T4 Explanation A. Insulin acts by Transmembrane Enzyme activating receptor. B. Corticosteroid has intracellular receptors. C. Epinephrine acts by Membrance Receptor. D. Glucagon acts by Membrane Receptors. Comments After the exam, the answer for this question was not debated and it was found that most had attempted even though they knew that the question is wrong !!! Tips If you feel that there is a mistake in the question and ONLY one of the choices could be the right choice if the question was corrected then go for it. On the other hand, if more than one choice can turn out to be the correct answer for a correct Question you will be risking a negative mark Question. 40. All of the following statements are correct about potassium balance, except: A. Most of potassium is intracellular. B. Three quarter of the total body potassium is found in skeletal muscle. C. Intracellular potassium is released into extra-cellular space in response to severe injury. D. Acidosis leads to movement of potassium from extracellular to intracellular fluid compartment. Answer D. Acidosis leads to movement of potassium from extracellular to intracellular fluid compartment. Ref: Ganong 20th Edition Page 30 Harrison 15th Edition Page 278 Quality: Reader Status: Repeat QTDF: Discussion Potassium is a major intracellular cation and is one of the determinants of Resting membrane potential as well as the process of Depolarisation and Repolarisation Total body stores account to 150 gms and the skeletal muscle stores is 110 gms 98 % intracellular and 2 % extracellular Intracellular concentration maintained by Na+K+ATPase Pump Q#P#I#x##########ot the answer. Read the basics of Autonomic SystC. Gelfiltration chromatography uses the molecular weight or size of the molecules. D. Chromatography on a diethylaminoethly (DEAE) cellulose column is Ion Exchange Chromatography. Comments Types of Chromatography Adsorption Chromatography Adsorption chromatography is probably one of the oldest types of chromatography around. It utilizes a mobile liquid or gaseous phase that is adsorbed onto the surface of a stationary solid phase. The equilibriation between the mobile and stationary phase accounts for the separation of different solutes. 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X-ray diffraction. Answer D. X ray diffraction Ref: Harper,25th Edtion Pg-56 may appear to indicate NMR but Harper 25th Edition Pg 55 Harper 24th Edition Pg10 : The most detailed information is by X-Ray Diffraction and Crystallography Harrison 15th Edition Chapter 322 -GOUT AND OTHER CRYSTAL ARTHROPATHIES Harrison 15th Edition Chapter 327 Principles of Endocrinology Campbells Urology 8th Edition Page 3274 mention option 4 as the investigating modality in revealing structures of microcrysta Quality: Spotter If you had already read the Ref:s shown above Status: New QTDF: Harrison Discussion The use of polarizing microscopy during synovial fluid analysis and the application of other crystallographic techniques, such as electron microscopy, energy-dispersive elemental analysis, and x-ray diffraction, have established the role of different microcrystals, including monosodium urate (MSU), calcium pyrophosphate dihydrate (CPPD), calcium hydroxyapatite (HA), and calcium oxalate (CaOx), in inducing acute or chronic arthritis or periarthritis. The family of nuclear receptors has grown to nearly 100 members, many of which are still classified as orphan receptors because their ligands, if they exist, remain to be identified . Otherwise, most nuclear receptors are classified based on the nature of their ligands. Though all nuclear receptors ultimately act to increase or decrease gene transcription, some (e.g., glucocorticoid receptor) reside primarily in the cytoplasm, whereas others (e.g., thyroid hormone receptor) are always located in the nucleus. After ligand binding, the cytoplasmically localized receptors translocate to the nucleus. The structures of nuclear receptors have been extensively studied, including by x-ray crystallography. X-ray crystallography shows that various SERMs induce distinct receptor conformations. Explanation 1 .Fluorescence spectroscopy: When a primary x-ray excitation source from an x-ray tube or a radioactive source strikes a sample, the x-ray can either be absorbed by the atom or scattered through the material. The process in which an x-ray is absorbed by the atom by transferring all of its energy to an innermost electron is called the photoelectric effect. During this process, if the primary x-ray had sufficient energy, electrons are ejected from the inner shells, creating vacancies. These vacancies present an unstable condition for the atom. As the atom returns to its stable condition, electrons from the outer shells are transferred to the inner shells and in the process give off a characteristic x-ray whose energy is the difference between the two binding energies of the corresponding shells. Because each element has a unique set of energy levels, each element produces x-rays at a unique set of energies, allowing one to non-destructively measure the elemental composition of a sample. The process of emissions of characteristic x-rays is called X-ray Fluorescence, or XRF. Analysis using x-ray fluorescence is called X-ray Fluorescence Spectroscopy. In most cases the innermost K and L shells are involved in XRF detection. A typical x-ray spectrum from an irradiated sample will display multiple peaks of different intensities. This is similar to the absorbtion spectrometry we use for determining the various forms of Hemoglobin (given in Chaterjee Biochemistry and Narayana Reddy FM Blood stains) but instead of the visible light we use in Hb determination, we use X-Rays here B. Electron microscopy.: Electron Microscopes are scientific instruments that use a beam of highly energetic electrons to examine objects on a very fine scale. This examination can yield the following information: Topography : The surface features of an object or how it looks, its texture; direct relation between these features and materials properties (hardness, reflectivity...etc.) Morphology : The shape and size of the particles making up the object; direct relation between these structures and materials properties (ductility, strength, reactivity...etc.) he loop of Henle is tX,@ l ,@ l ,@ l ,@ l X,@ l #X ,@ l ,@ l ,@ l ,@ l ,@ l 8hXXX!X,@ l !X,@ l ?,@ l L,@ l A,@ l ,@ l ,@ l ,@ l ,@ l ,@ l ,@ l ,@ l .,@ l ZGdZGdZGdZGdZGdZGdZGdZGdZGdZGdZGdZGdZGd ZGdZGdZGdZGdZGdZGdZGdZGdZGdZGdZGdZGdZGd ZGdZGd*ZGdZGd ZGdZGdZGd ZGdZGdZZGd ZGdZGd;ZGd ZGdZGd2ZGdZGdZGdZGdZGdWZGdZGdZGdZGd9ZGdZGdZGdZGdZGdZGd ZGd ZGdZGdZGd)ZGd ZGdZGdZGd]ZGdWZGdZGdZGdZGdZGdZGdZGd*ZGd ZGdZGd(ZGdZGdZGdZGdZGdZGd ZGdZGdZGd ZGdZGdZGd ZGdZGdZGdZGd(ZGd7ZGdzZGdZGdZGdZGdZGd ZGdZGdZGdZGdZGd ZGd8ZGdZGdZGdZGdZGdZGdZGdZGdZGdZGdZGdZGdZGd?ZGd#ZGdZGd'ZGdZGdZGd(ZGdZGdZGdZGdZGd ZGdZGdZGdZGdZGdZGd ZGd ZGd.ZGd ZGdZGdZGdZGd5b5b005c5c5c005d5d5d005e5e5e005f5f5f0060606000616161006262 Composition : The elements and compounds that the object is composed of and the relative amounts of them; direct relationship between composition and materials properties (melting point, reactivity, hardness...etc.) C. Nuclear magnetic resonance spectroscopy is a powerful and theoretically complex analytical tool technique used for determining the content and purity of a sample as well as its molecular structure. For example, NMR can quantitatively analyze mixtures containing known compounds. For unknown compounds, NMR can either be used to match against spectral libraries or to infer the basic structure directly. Once the basic structure is known, NMR can be used to determine molecular conformation in solution as well as studying physical properties at the molecular level such as conformational exchange, phase changes, solubility, and diffusion. In order to achieve the desired results, a variety of NMR techniques are available. D. X-ray diffraction The term x-ray diffraction refers to the diffraction of x-rays by a crystal. The wavelengths of x-rays are comparable in size to the distances between atoms in most crystals, and the repeated pattern of the crystal lattice acts as a diffraction grating for x-rays. Comments The term x-ray powder diffraction refers in general to x-ray diffraction of a collimated monochromatic beam by a sample (a powder) containing a large number of tiny crystals having random orientations. The term x-ray crystallography refers to the use of x-ray diffraction to determine the structure of crystals or molecules. In general, the technique involves directing a beam of x-rays at a crystalline sample and recording the diffracted x-rays on a photographic plate. The x-ray diffraction pattern consists of a pattern of spots on the plate, and the crystal structure can be determined from the positions and intensities of the diffraction spots. Since x-rays are diffracted by the electrons in a molecule, if molecular crystals of a compound are used, the electron density distribution in the molecule can be determined. X-ray diffraction is currently one of the most important tools of solid-state physics and chemistry, the technique used for differentiation between crystalline and amorphous materials, determination of the structure of crystalline materials, determination of electron distributions within atoms and throughout unit cells of a crystal, determination of the orientation of single crystals, determination of the texture of polygrained materials, etc. In the biological sciences, x-ray diffraction has contributed greatly to our understanding of processes occurring in living cells, with the technique revealing the structures of proteins and nucleic acids and their constituent monomers, and also of drugs, hormones, and vitamins. Knowledge of 3-dimensional structures of various biomolecules has had a profound impact on the whole of biology. Tips Question. 46. Porphobilinogen in urine produces pink color with: A. Fouchets reagent. B. Benedicts reagent. C. Sodium nitropruside. D. Ehrlich s aldehyde reagent. Answer D. Ehrlich s aldehyde reagent. Ref: J.Sengupta,SynopsisOfClinicalPathology&Microbiology,5th,Pg-82 Textbook of Medical Biochemistry 4th Edition Chaterjee and Shinde Page 477 Chaterjee and Sinde 2nd Edition Page 322 Chapter on Porphyrias Quality: Spotter Status: New QTDF: Chaterjee Discussion Watson and Schwartz Test for Porphobilinogen Procedure A. Mix Equal Volume of Fresh urine and Ehrlich Reagent (0.7 gm of p-dimethyl amino benzaldehyde + 150 ml of Conc HCl and 100 ml Distilled water) B. Allow to stand for 3 minutes C. To this add saturated aqueous Sodium Acetate Solution (2 volumes) and D. Leave for 3 minutes 5. Add a few ml of Chloroform 6. Shake thoroughly 7. Porphobilinogen forms a red aldehyde compound which (unlike that formed by urobilinogen) is insoluble in Chloroform Interpretation: Red colour after second extraction with chloroform means a positive test for Porphobilinogen and highly suggestive of Acute Intermittent Porphyria. On the other hand if the chloroform becomes pink it is Urobilinogen Explanation A. Fouchets reagent detects bile pigments. B. Benedicts reagent All of you will know one Benedicts reagent, but there is another also !!! (See Uric Acid in the Table Below) C. Sodium nitropruside is used along with Ammonium Sulphate for detection of Ketones in Rohtera Test. D. Ehrlich s aldehyde reagent. Is used as above Comments The table below is incomplete and should not be used for studying. A complete table is beyond the scope of this book, but may be found at www.rxpg.com, www.rxpgonline.com and www.targetpg.com. This is for refreshing your memory. Only the reagents are dealt with and the procedures are not given for want of space Few points about Urine Analysis Substance Detected Name of the Test Reagent Colour Chloride Fantus AgNO3 White Sulphate Acetic Acid, BaCl2 White Ethereal Sulphates Acetic Acid, BaCl2 ,HCl Turbidity Indiacan Jaffe Hypochlorite(K Chlorate and Conc HCl) Extract with Chloroform Indigo blue Oberneyers Ferric Chloride + HCl Extract with Chloroform Indigo blue Calcium Sulkowich Oxalic Acid, Ammonium Oxalate and Glacial Acetic Acid Fine white cloud or Heavy Milky White Urea Hypobromite Sodium Hypobromite Effervescence Specific Urease Phenol Red, 1% Acetic Acid or 2% Na2CO3 Faint Yellow Red Specific Urease Above Test + 1 ml of Urease + shake and wait for 10 minutes Intense Pink Colour Doremus Ureometer Uric Acid Benedicts Uric Acid test Benedicts Uric Acid Reagent + Na2CO3 Blue Colour Murexide Test Conc HNO3 + Heat Reddish Deposit Above Test+ dip a rod in dil NH3 and draw it through the deposit Reddish Violet Deposit + NaOH Bluish Violet Protein Heat Test Test Tube Heated Precipitate Sulphosalicylic Acid Test 25 % Sulphosalicylic Acid White Precipitate Nitirc Acid test Conc HNO3 White Ring Sugar Benedicts 5ml of Benedicts Qualitative Reagent + 8 drops of Urine Colour Change from Blue to Red Fehlings Fehlings reagent A + B Ketone Bodies Rothera Ammonium Sulphatre + Sodium Nitroprusside Purple Ring Gerhardts 10 % Ferric Chloride Purple Colour Iodoform Test Alkaline Iodine Beta OH butyric Acid Black reaction H2O2 Ferric and Ferrous Chloride Rose Colour 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Partition Chromatography This form of chromatography is based on a thin film formed on the surface of a solid support by a liquid stationary phase. Solute equilibriates between the mobile phase and the stationary liquid. 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Ion Exchange Chromatography In this type of chromatography, the use of a resin (the stationary solid phase) is used to covalently attach anions or cations onto it. Solute ions of the opposite charge in the mobile liquid phase are attracted to the resin by electrostatic forces. [* | In-line.WMF 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fffffffffffffffffefffffdfffffffffefcfefefffffffffffffffffffffffffffffffefefefefefffdfdfefffefffdfefffffffffffffffffffffffffffffffffffffefefefefffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffefffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffdfeffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffff00fdfaf5f4fffdfdfbfaf7f3f3f9f4fefaf9fcfefafafdfefffefffffffbfefffbfffefefefefffffffffffffefcfffffffffffffefbfffffffffffffffffffffffffffffffffffffffefffffffffffefffefefffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffefefffffffffffffffffffffffffffffffffefefefefefffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffefdfffffffffffffefefffffffffffffefdffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffff00f7f9f9f7faf9f8f6f9f8f7fcf5fff5f6f4f9fcfefffcfefffefffffffcfffefdfffffffffffffffffffffefefdfffffffffffffffcfffffffffffffffffffffffffffffffffffffffffdfff9f2fffefffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffefffffffffffffffffffffffffffffffffffffffffefffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffefffffffffffffffefffffffffefefefcffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffff00fefbf8f6fbfafffaf7f5f5f5f7f5fdf3fff9fafaf8fcfffefffffefffffffefffefffffffffffffffffefefefffefefefefefefffffffffffffffffffffffffffffffffffffffffffefffffefcfffefffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffefffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffdfefffeffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffff000400000007010100030000000000 Molecular Exclusion Chromatography Also known as gel permeation or gel filtration, this type of chromatography lacks an attractive interaction between the stationary phase and solute. The liquid or gaseous phase passes through a porous gel which separates the molecules according to its size. The pores are normally small and exclude the larger solute molecules, but allows smaller molecules to enter the gel, causing them to flow through a larger volume. This causes the larger molecules to pass through the column at a faster rate than the smaller ones. [* | In-line.WMF 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Affinity Chromatography This is the most selective type of chromatography employed. It utilizes the specific interaction between one kind of solute molecule and a second molecule that is immobilized on a stationary phase. For example, the immobilized molecule may be an antibody to some specific protein. When solute containing a mixture of proteins are passed by this molecule, only the specific protein is reacted to this antibody, binding it to the stationary phase. This protein is later extracted by changing the ionic strength or pH. [* | In-line.WMF 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AIPG 2003 of the 11 Questions from Anaesthesia 6 were Spotters from SARP and other books and that every one will attempt and you should not leave this 5 Questions were from Miller and Lee. Most of the first timers will answer wrongly; a few experienced will leave these questions and the rare anesthetists (who have finished DA) will get it right. 1. An anesthetist orders a new attendant to bring the oxygen cylinder. He will ask the attendant to identify the correct cylinder by following color code: A. Black cylinder with white shoulders. B. Black cylinder with gray shoulders. C. White cylinder with black shoulders. D. Grey cylinder with white shoulders. Answer: A (Black cylinder with white shoulders) Ref: Understanding Anaesthesia Equipments 4th Edition Dorsch and Dorsch,13; Lee 12th edn, 104; SARP 6th edn,95; PARAS 4th edn, 31; Ramgopal 1st, 84 Quality: Spotter Status: High Yield Topic QTDF: All books give this concept Discussion Cylinders used for Storing Anaesthetic Agents (as well as other common gases used in wards) are given a standard colour code so the paramedical personal identify it with ease And the colour codes of the commonly used gases are as follows: Gas Cylinder colour Pin Pressure at 15oC In other countires In USA Index Lbf/in2 Bar Oxygen(O2) Black body with Green 2-5 1987 137 white shoulder Nitrous Oxide French Blue Blue 3-5 638 44 (N2O) Cyclopropane Orange Orange 3-6 73 5 Carbon Di Oxide Grey Grey 1-6 725 50 (CO2) Halothane bottle Amber Ethylene bottle Red Helium (He) Brown Brown 1987 137 Entonoc Blue body with Blue/ 7 1987 137 white shoulder Green Air Grey body with Yellow 1-5 1987 137 B & White shoulder O2/Helium Black Green/ 4-6,2-4 1987 137 Brown O2/CO2 Black Green / 2-6,1-6 1987 137 Grey Nitrogen 1-4 Explanation A. This is the correct colour code of Oxygen B. Not a recognised colour code C. Not a recognised colour code D. This is the colour code for Air Comments Few agents are in bottles rather than in cylinders Gases Bottle Colour Halothane Amber Ethylene Red Sometimes the supply is through pipes and we have a few details here also Gas Hose Colour Socket Colour Pressure Oxygen(O2) White White 4 Bar Nitrous Blue Blue 4 Bar Oxide (N2O) Air Black Black 7 Bar Suction Yellow Yellow The boiling points of the Anaesthetic agents also are worth remembering Gas Boiling Point Ethylene Chloride 12.5 oC Desflurane 23 oC Ether 34.6 oC Isoflurane 45.5 oC Halothane 50 oC Enflurane 56.5 oC Sevoflurane 58.5 oC Tricholoroethylene 86 oC Nitrous Oxide 89 oC Methoxyflurane 104 oC Tips Please dont try to visualise the oxygen cylinders you might have seen in your Operation theatres (When not properly painted or maintained they might have appeared in colours other than black). 2. A 25 years old male is undergoing incision and drainage of abscess under general anesthesia with spontaneous respiration. The most efficient anaesthetic circuit is: A. Mapleson A. B. Mapleson B. C. Mapleson C. D. Mapleson D. Answer: A (Mapleson A) Ref: Understanding Anaesthesia Equipments 4th Edition Dorsch and Dorsch, 209; SARP-SARP 6th edn, 94; PARAS - PARAS 4th edn, 32; Ramgopal 1st edn,87 Quality: Spotter Status: Repeat QTDF: All books give this concept Discussion Breathing system is classified as: A. Open - No rebreathing. B. Semiclosed - Partial rebreathing C. Closed - Total rebreathing In 1954, Mapleson classified anaesthetic breathing systems into A,B,C,D& E. Mapleson F breathing system was later added. The Fresh Gas flow rate required to prevent rebreathing of alveolar gas is a measure of efficiency of a breathing system Explanation A. Mapleson A. is the preferred circuit for spontaneous respiration and here the fresh gas flow in spontaneous breathing is equal to patients minute volume and in controlled ventilation is equal to 3 x minute ventilation B. Mapleson B is not used commonly and it requires twice the patients minute volume. C. Mapleson C is not used commonly and it requires twice the patients minute volume. Its compactness makes it useful during resuscitation and transportation of ventilated patients (in intensive care units) It is also called as Waters System D. Mapleson D is best suited for controlled ventilation. Comments In short for Spontaneous breathing the preferred circuit is A followed by D,C,B For controlled breathing, the preferred circuit is D followed by B,C,A Tips For detailed discussion, serious viewers can read Dorsch and Dorsch. Sure Success in PG book for Skin, Psy, Derm, RD and RT gives the salient points 3. A 38 year old man is posted for extraction of last molar tooth under general anaesthesia as a day care case. He wishes to resume his work after 6 hours. which one of the following induction agents is preferred: A. Thiopentone sodium B. Ketamine. C. Diazepam. D. Propofol Answer: D (Propofol) Ref: Clinical Anaesthesia 3rd edn Morgan, 173; KDT 4th edn, 352; Lee 12th edn, 417; SARP - SARP 6th edn, 108; PARAS -PARAS 4th edn, 46; Sure Sucess in PG Entrance 1st edn, 93 Quality: Spotter Status: Repeat QTDF: All books give this Discussion  C,c=!Ch6@B<ca:CXBcaNCX!caDCXca0CX~cC,tca0CX~@BcC,@Bc.C,RcC,\ c C,cC,tC,c C,C6cC,@B, Cc6#,6#=##?#?#9#<#=#<#=#>#;#/CicC,c c,c@ /c#cC@ cc,#@  Cc7#,cC@ cca:)CXn caN.#Xh;#XhCXcaD0#Xh3CXoe (CaOx), in indA (xKdd) (xKddW (xKdd (xKdd9 (xKdd (xKdd (xKdd (xKdd (xKdd ,(xKdd (xKdd] (xKddi (xKddY (xKdd ,(xKddE (xKdd (xKddX(xKddd (xKdd (xKdd (xKdd (xKddX(xKddd (xKdd#X(xKddd (xKdd (xKdd (xKdd (xKdd (xKdd8h<(xKdddX(xKdddX(xKdddX(xKddd!X(xKddd (xKdd!X(xKddd (xKdd? 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(xKdd7 (xKddY(xKdddJ(xKdddy(xKddd (xKdd, (xKddX(xKddd X(xKdddX(xKdddX(xKddd$ (xKdd! (xKdd (xKdd (xKddh<(xKddd X(xKddd X(xKddd X(xKdddn of our population in the total population hh = Average house hold size Explanation A. Prevalence of the disease in population is needed. B. Power of the study is not needed. C. Significance level is needed. D. Desired precision is needed. Comments More information can be seen at the book quoted Tips When you see a question like this in exam, and you cant even know what it means, or from where the question has come from, then you have to go immediately to the next question J This is a theme couple. Theme couple means 2 questions are asked from the same topic in a Same Exam. Sometimes the 2 may be even the same question, and sometimes there will be a slight twist (or a trap) between the two Tips Be at look out for theme couples in AIPG and AIIMS Question papers While answering theme couples, You will get 8 marks when you get both right, -2 when you get both wrong and 3 if you get one right and the other wrong and 0 when you dont attempt. If you know the answer you can get 8 marks, but if there are doubts about the answer in the exam hall.. I will mark two different answers .what will you do?? 5. Induction agent that may cause adrenal cortex suppression is: A. Ketamine B. Etomidate. C. Propofol. D. Thiopentone Answer: B (Etomidate) Ref: Harrison 15th edn 328: ACTH; Harrison 15th edn Table 71-2; Lee 12th edn, 185; KDT 4th edn, 353; SARP-SARP 6th edn, 110; PARAS-PARAS 4th edn, 46; Sure Sucess in PG Entrance 1st edn, 94; Davidson, at the Endocrinology topic Quality: Spotter Status: Repeat QTDF: All books give this Discussion Etomidate is a short-acting hypnotic, which appears to have gamma-aminobutyric acid (GABA)-like effects. Unlike the barbiturates, etomidate reduces subcortical inhibition at the onset of hypnosis while inducing neocortical sleep. Studies in animals suggest that a part of the action of etomidate consists of a depression of the activity and reactivity of the brain stem reticular formation Etomidate is a non barbituate intravenous induction agent and it inhibits 11beta hydoxylase. It also causes Vitamin C deficiency and has a very high incidence of myoclonus and thrombophlebitis. It is contraindicated in Pregnancy. Explanation A. Ketamine increases all pressures and is contraindicated in pregnancy B. Etomidate is the answer. C. Propofol has already been dealt with and is associated with Pain and myotonic effects. D. Thiopentone exacerabates AIP in susceptible patients Comments Etomidate does not cause significant cardiovascular or respiratory depression, but may cause a brief period of apnea. Also, it does not appear to elevate plasma histamine or cause histamine release when administered in recommended doses. The decrease in cerebral blood flow produced by etomidate is approximately the same as that produced by thiopental and methohexital ; this reduction appears to be uniform in the absence of intracranial tumors. Etomidate slightly lowers intracranial pressure and it usually causes a moderate decrease in intraocular pressure Also, etomidate (at induction doses of 0.3 mg per kg of body weight [mg/kg]) has been reported to reduce plasma cortisol concentrations; this effect persists for 6 to 8 hours and appears to be unresponsive to adrenocorticotropic hormone (ACTH) Tips Other drugs causing Addisonian like syndrome include Busulfan and ketoconazole 6. At the end of a balanced anaesthesia technique with non-depolarizing muscle relaxant, a patient recovered spontaneously from the effect of muscle relaxant without any reversal. Which is the most probable relaxant the patient had received? A. Pancuronium. B. Gallamine. C. Atracurium. D. Vecuronium. Answer: C (Atracurium) Ref: Clinical Anaesthesia 3rd edn, Morgan 191; KDT 4th edn, 154; Lee 12th, 213; SARP-SARP 6th edn, 122; PARAS-PARAS 4th edn, 58; Sure Sucess in PG Entrance 1st edn, 102 Quality: Spotter Status: Repeat QTDF: All books (except Tripathi) give this. Tripathi says vecuronium !!! Discussion Balanced Anaesthesia (introduced by Lundy) is: 1. Thiopentone for induction 2. N2O for Amnesia 3. Opiod for Analgesia 4. Curare for Muscle relaxation Atracurium is Benzylisoquinoliniums Undergoes Hoffmans degradation at body temperature Stored at 4oC Relaxant of choice in patients with hepatic or renal dysfunction Suitable for patients with Atypical Cholinesterase, Organophosphorus poisoning and in myasthenia gravis Contraindicated in Asthma Side effect is Histamine release Metabolite is laudanosine which is a CNS Derivative Explanation Do we need an explanation !! 1. Pancuronium.is not used in liver failure 2. Gallamine is totally excreted by kidney 3. Atracurium undergoes Hoffmans degradation 4. Vecuronium is safe in Liver failure and has no Cardiovascular side effects and does not release histamine Comments Atracurium undergoes Hoffman degradation (95%) and also ester hydrolysis (5%) in plasma. Tips Xenobiotics can hurl a question at you in unexpected places. Be prepared !!! 7. During rapid sequence induction of anesthesia: A. Selicks maneuver is not required. B. Pre-oxygenation is mandatory. C. Suxamethonium is contraindicated. D. Patient is mechanically ventilated before end tracheal incubation. Answer: B (Pre-oxygenation is mandatory) Ref: Miller 5th edn, 434; Lees Synopsis of Anaesthesia 12th, 388 Arteries QTDF: Any Anatomy6Xj,@ l j,@ l ?,@ l X ,@ l ,@ l ,@ l ,@ l B,@ l R,@ l ",@ l ,@ l ,@ l -,@ l ,@ l ,@ l ,@ l ,@ l ,@ l ,@ l ),@ l ZX,@ l XwX@Xripathi says vecuronium !!! Discussion Balanced Anaesthesia (introduced by Lundy) is: 1. Thiopentone for induction 2. N2O for Amnesia 3. Opiod for Analgesia 4. Curare for Muscle relaxation Atracurium is Benzylisoquinoliniums Undergoes Hoffmans degradation at body temperature Stored at 4oC Relaxant of choice in patients with hepatic or renal dysfunction Suitable for patients with Atypical Cholinesterase, Organophosphorus poisoning and in myasthenia gravis Contraindicated in Asthma Side effect is Histamine release Metabolite is laudanosine which is a CNS Derivative Explanation Do we need an explanation !! 1. Pancuronium.is not used in liver failure 2. Gallamine is totally excreted by kidney 3. Atracurium undergoes Hoffmans degradation 4. Vecuronium is safe in Liver failure and has no Cardiovascular side effects and does not release histamine Comments Atracurium undergoes Hoffman degradation (95%) and also ester hydrolysis (5%) in plasma. Tips Xenobiotics can hurl a question at you in unexpected places. Be prepared !!! QUESTION. 07. During rapid sequence induction of anesthesia: 1.Selicks maneuver is not required. 2.Pre-oxygenation is mandatory. 3.Suxamethonium is contraindicated. 4.Patient is mechanically ventilated before end tracheal incubation. Answer 2.Pre-oxygenation is mandatory. Ref: Miller 5th Edition Page 434 Lees Synopsis of Anaesthesia 12th Page 388 C,cGdZ#################0##################T##############~###v##|####################################A####################################################x### ###y########Quality: Reader Status: New Question QTDF: Miller, Lee Discussion In rapid sequence induction, induction is done after pre-oxygenation for 4-5 minutes, induction agent (thiopentone) is given followed immediately by succinylcholine (suxamethonium). Ventilation with bag and mask is not done because with bag and mask ventilation the air leak into stomach can raise intragastric pressure to more than 28 cm H2O (Critical pressure for aspiration) easily - An assistant applies pressure over cricoid (Sellicks manoeuvre) to prevent regurgitation and intubation is done with a small size endotracheal tube and cuff of endotracheal tube is inflated. If the intubation fails, spontaneous ventilation should be allowed to return and awake intubation performed. After surgery, patient should remain intubated until airway reflexes and conciousness return Explanation A. Sellick smaneuver is done B. Pre oxygenation is done for 4 to 5 minutes C. Suxamethonium is given D. Mechanical ventilation is not done for the fear of filling up stomach with gas and there by potentiating vomiting Comments A new question in Anaesthesia out of our regular books we follow(SARP etc) Tips Questions like these are proof that solving AIPG and AIIMS question papers require in-depth knowledge of the subjects 8. A 5-year-old boy suffering from Duchenne muscular dystrophy has to undergo tendon-lengthening procedure. The most appropriate anaesthetic would be: A. Induction with intravenous thiopentone and N2O; and halothane for maintenance. B. Induction with intravenous propofol and N2O; and oxygen for maintenance. C. Induction with intravenous suxamethonium and N2O; and halothane for maintenance. D. Inhalation induction with inhalation halothane and N2O; oxygen for maintenance. Answer: B (Induction with intravenous Propofol and N2O; and oxygen for maintenance) Ref: Miller 5th edn, 422; Nelson 15th edn Quality: Thinker Status: Repeat from AIIMS QTDF: Miller Discussion ANAESTHESIA IN A CASE OF NEUROMUSCUALR DISEASE: In neuromuscular diseases, anaesthesia of choice is peripheral nerve blocks, local and central neuraxial block (below T9). If GA is to be given than it should be contemplated with total intravenous anaesthesia (propofol + fentanyl) and maintained on oxygen, nitrous oxide and opioid. Relaxation, if needed ,is achieved by inhalational agents and if sufficient relaxation is not achieved by them non depolarizing relaxants like atracurium should be given and dose is adjusted according to neuromuscular monitoring response. Halothane causes MALIGNANT HYPERPYREXIA and should not be used. Succinyl Choline causes Intractable Cardiac Arrest in a child with Duchenne Muscular Dystrophy Another view is that, for a normal patient, In any surgery involving muscle lengthening / shortening, the dictum is not using Ether / Halothane which can alter the tension of the muscle and use N2O which has no effect on muscles.... Explanation A. Halothane cannot be used B. This is the correct answer C. Both Succinyl Choline as well as Halothane cannot be used and this seems to be a preposterous choice !! D. Halothane cannot be used Comments Malignant Hyperthermia occurs in individuals with an inherited abnormality of skeletal-muscle sarcoplasmic reticulum that causes a rapid increase in intracellular calcium levels in response to halothane and other inhalational anesthetics or to succinylcholine. Elevated temperature, Increased muscle metabolism, Rigidity, Rhabdomyolysis, Acidosis, and Cardiovascular instability develops rapidly. This condition is often fatal. Earliest sign Masseter Muscle Rigidity Other signs Tachycardia, Hybercarbia Triggering Drugs Protective Drugs Enflurane, Isoflurane, Nitrous Oxide Desflurane, Sevoflurane, Droperidol Methoxy Flurane Local Anaesthetics Succinyl Choline Etomidate Pancuronium Propofol Thiopentone Ketamine m To be treated immediately m Cessation of anesthesia and m Intravenous administration of dantrolene sodium. u The recommended dose of dantrolene is 1 to 2.5 mg/kg of body weight given intravenously every 6 h for at least 24 to 48 h-until oral dantrolene can be administered, if needed. u Dantrolene at similar doses is indicated in the 3 Neuroleptic malignant syndrome. 3 In drug-induced hyperthermia and may even be useful in the 3 Hyperthermia of Thyrotoxicosis. m Procainamide should also be administered to patients with malignant hyperthermia because of the likelihood of ventricular fibrillation in this syndrome. The neuroleptic malignant syndrome can occur with phenothiazines and other drugs such as haloperidol and is Characterized by u Muscle rigidity, u Autonomic dysregulation, and u Hyperthermia. This disorder appears to be caused by the u Inhibition of central dopamine receptors in the hypothalamus, u Which results in Increased heat generation and u Decreased heat dissipation. u Thyrotoxicosis and pheochromocytoma can also cause increased thermogenesis. The neuroleptic malignant syndrome may also be treated with u Bromocriptine, u Levodopa, u Amantadine, or u Nifedipine or u By induction of muscle paralysis with curare and pancuronium. u Tricyclic antidepressant overdose may be treated with physostigmine Tips A repeat question from AIIMS. May be you will get this is future too Read the basics about the anaesthesia in certain disease conditions and physiological states Drugs causing Malignant Hyperthermia are SCHEMe Succinyl Choline Cyclopropane Halothane Ether MethoxyFlurane QUESTION. 09. In all of the following conditions neuraxial blockade is absolutely contraindicated, except: A. Patient refusal. B. Coagulopathy C. Severe hypovolemia. D. Pre-existing neurological deficits. Answer D. Pre-existing neurological deficits. Ref: Clinical Anaesthesia 3rd Edition Morgan Page 262 Also can be Seen at Lee 12th Edition Page 369 PARAS - PARAS 4th Edition: Page 66 Quality: Reader Status: New Question QTDF: Morgan Discussion Neuraxial block means spinal and epidural anesthesia as well as Caudal Blocks and here the agent acts at the level of the Nerve Root. There are a few Absolute and Few Relative contraindiations for Spinal and Epidural Anaesthesis. The Absolute contraindications are A. Infection at the site of Injection B. Patient refusal C. Coagulopathy D. 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(xKdd (xKdd (xKdd (xKdd (xKdd (xKdd (xKddGdZGC. Leaves extension at elbow joint intact. Ref: Snells,6th,Pg-493, AKDutta,Pg-66 BDC Vol 1 Page 90 Grays Anatomy 38th Edition Page 1274 Quality: Reader Status: Repeat QTDF: All books Discussion BDC describe the branches of Radial Nerve only under the following headings A. Before Spiral Groove Long Head of Triceps Medial Head of Triceps B. In Spiral Groove Long Head of Triceps Lateral Head of Triceps Medial Head of Triceps Ancomeus C. After Spiral Groove Brachialis Brachoradialis Extensor Carpi Radialis Gray describes the muscular branches as below These supply the triceps, anconeus, brachioradialis, extensor carpi radialis longus and brachialis in medial, posterior and lateral groups. Medial muscular branches u Arise from the radial nerve on the medial side of the arm. u They supply the Medial head of Triceps -the branch to the medial being a long, slender filament which, lying close to the ulnar nerve as far as the distal third of the arm, is often termed the ulnar collateral nerve. Long heads of the triceps, A large posterior muscular branch u Arises from the nerve as it lies in the humeral groove. u It divides to supply the Medial and Lateral heads of the triceps and the Anconeus, that for the latter being a long nerve which descends in the medial head of the triceps and partially supplies it; it is accompanied by the middle collateral branch of the arteria profunda brachii and passes behind the elbow joint to end in the anconeus. Lateral muscular branches u Arise in front of the lateral intermuscular septum; u Supply the Lateral part of the brachialis, Brachioradialis and Extensor carpi radialis longus. So, in any injury is the lower part of Spiral Groove, we have to assume that the posterior Muscle branch has escaped. So triceps will not be affected and Anconeus has its nerve supply intact Lesions of Radial Nerve At Axilla Loss of Elbow Extension Loss of Sensation in the lateral and posterior Part of Arm Loss of Wrist Extension - Wrist Drop Loss of Thumb Extension - Thumb drop Loss of Finger Extension - Finger drop Loss of Sensation in the first dorsal web space At the lower end of Spiral Groove Loss of Wrist Extension - Wrist Drop Loss of Thumb Extension - Thumb drop Loss of Finger Extension - Finger drop Loss of Sensation in the first dorsal web space After Spiral Groove Before Piercing the Supinator and before the origin of sensory branch Diminished Wrist Extension - Wrist Deviates radially when extended Loss of Thumb Extension - Thumb drop Loss of Finger Extension - Finger drop Loss of Sensation in the first dorsal web space After Piercing the Supinator (Posterior Interosseus Nerve) Loss of Thumb Extension - Thumb drop Loss of Finger Extension - Finger drop Superficial Branch It lies superficially and relatively unprotected overlying the lateral aspect of the radius, where it is easily compressed by tight bracelets, watch straps and handcuffs, Called as Cheralgia Paraesthetica (compare with Meralgia Paraesthetica) Loss of Sensation in the first dorsal web space If the lesion is proximal in this nerve, sensation may be impaired over a variable area of skin over the lateral side of the dorsum of the hand. Explanation A. Nerve supply to extensor carpiradialis longus is not spared B. Does not result in paralysis of anconeus muscle as the Posterior Muscle branch escapes because it arises in the spiral groove and the injury is in the lower part of the spiral groove. C. Leaves extension at elbow joint intact as the Triceps is supplied by Medial and Posterior Branches both of these arise above the lower part of Spiral Groove D. Does not weaken the pronation. In fact it is the only movement not supplied by Radial Nerve !! Comments The Catch in this question is the LOWER part of Spiral Groove. If the same injury has happened in the Spiral Groove then Anconeus will be paralysed and extension of elbow will not be intact. Then we have to go for choice 2 Radial Nerve Extends, Flexes (by supplying Bracho Radialis, which is morphologically a extensor and functionally a flexor and Brachialis which has a dual nerve Supply along with Musculocutaneous Nerve) and also Supinatesbut it does not supply pronation Tips Other nerve Injuries Lesions of the Median Nerve Median nerve lesions occur at two sites, A. In the forearm (Pronator Syndrome) and B. At the wrist. (Carpal Tunnel Syndrome) Pronator Syndrome This is an uncommon entrapment neuropathy of the median nerve Sites The nerve may be involved at any of these sites. A. As it passes alongside the fibrous band connecting the biceps tendon to the forearm fascia, B. As it passes down between the two heads of pronator teres C. As it passes through a fibrous arch formed by flexor digitorum superficialis. Symtoms and Signs Motor There is weakness of all the muscles innervated by the median nerve, including abductor pollicis brevis and the long finger flexors. Sensory There is also sensory impairment on the palm of the hand(spared in the carpal tunnel syndrome because the palmar cutaneous branch of the median nerve arises above the carpal tunnel and lies superficial to it.) Anterior interosseous nerve palsy The anterior interosseous nerve usually arises from the median nerve proximal to the site of compression in the pronator syndrome; it may be affected with the median nerve or by itself. Causes 1. Due to external pressure(a form of Saturday night palsy), B. Sometimes by tight grip in association with pronation without obvious cause. C. May be a manifestation of neuralgic amyotrophy and tends to resolve spontaneously over several months. Motor: An anterior interosseous nerve palsy causes weakness of pinch grip due to involvement of flexor pollicis longus and flexor digitorum profundus to the index finger. Please note that Innervation of flexor digitorum profundus to the middle finger is rather variable,(also by Ulnar Nerve) therefore this muscle may or may not be weak. The branches to these three muscles (FDP,FPL,PQ)may arise separately from the median nerve, so that isolated weakness of the terminal phalanx to the thumb or index finger may occur. The pronator quadratus is also involved but is not clinically significant. Carpal Tunnel Syndrome This is the most common entrapment mononeuropathy caused by the compression of the median nerve as it passes through the fibro-osseous tunnel beneath the flexor retinaculum. Causes The carpal tunnel may be narrowed by A. Arthritic changes in the wrist joint, particularly rheumatoid arthritis; B. Soft tissue thickening as may occur in myxoedema and acromegaly; C. Edema and obesity including pregnancy. Pathology Normally the nerve slides smoothly in and out of the carpal tunnel with flexion and extension of the wrist; when the nerve is compressed there is an additional damage to the nerve with flexion and extension. The dominant hand is usually affected first, probably because this hand is used more frequently and more vigorously. Motor There is wasting and weakness of abductor pollicis brevis Sensory Impairment of sensation in the A. Thumb, B. Index Finger, C. Middle Fingerand D. 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Low levels of oxygen leads to decreased glycolytic activity (of course) but not the opposite as given in this choice. 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Theme couple means 2 questions are asked from the same topic in a Same Exam. Sometimes the 2 may be even the same question, and sometimes there will be a slight twist (or a trap) between the two Tips Be at look out for theme couples in AIPG and AIIMS Question papers While answering theme couples, You will get 8 marks when you get both right, -2 when you get both wrong and 3 if you get one right and the other wrong and 0 when you dont attempt. If you know the answer you can get 8 marks, but if there are doubts about the answer in the exam hall.. I will mark two different answers .what will you do?? 5. Induction agent that may cause adrenal cortex suppression is: A. Ketamine B. Etomidate. C. Propofol. D. Thiopentone Answer: B (Etomidate) Ref: Harrison 15th edn 328: ACTH; Harrison 15th edn Table 71-2; Lee 12th edn, 185; KDT 4th edn, 353; SARP-SARP 6th edn, 110; PARAS-PARAS 4th edn, 46; Sure Sucess in PG Entrance 1st edn, 94; Davidson, at the Endocrinology topic Quality: Spotter Status: Repeat QTDF: All books give this Discussion Etomidate is a short-acting hypnotic, which appears to have gamma-aminobutyric acid (GABA)-like effects. Unlike the barbiturates, etomidate reduces subcortical inhibition at the onset of hypnosis while inducing neocortical sleep. Studies in animals suggest that a part of the action of etomidate consists of a depression of the activity and reactivity of the brain stem reticular formation Etomidate is a non barbituate intravenous induction agent and it inhibits 11beta hydoxylase. It also causes Vitamin C deficiency and has a very high incidence of myoclonus and thrombophlebitis. It is contraindicated in Pregnancy. Explanation A. Ketamine increases all pressures and is contraindicated in pregnancy B. Etomidate is the answer. C. Propofol has already been dealt with and is associated with Pain and myotonic effects. D. Thiopentone exacerabates AIP in susceptible patients Comments Etomidate does not cause significant cardiovascular or respiratory depression, but may cause a brief period of apnea. Also, it does not appear to elevate plasma histamine or cause histamine release when administered in recommended doses. The decrease in cerebral blood flow produced by etomidate is approximately the same as that produced by thiopental and methohexital ; this reduction appears to be uniform in the absence of intracranial tumors. Etomidate slightly lowers intracranial pressure and it usually causes a moderate decrease in intraocular pressure Also, etomidate (at induction doses of 0.3 mg per kg of body weight [mg/kg]) has been reported to reduce plasma cortisol concentrations; this effect persists for 6 to 8 hours and appears to be unresponsive to adrenocorticotropic hormone (ACTH) Tips Other drugs causing Addisonian like syndrome include Busulfan and ketoconazole 6. At the end of a balanced anaesthesia technique with non-depolarizing muscle relaxant, a patient recovered spontaneously from the effect of muscle relaxant without any reversal. Which is the most probable relaxant the patient had received? A. Pancuronium. B. Gallamine. C. Atracurium. D. Vecuronium. Answer: C (Atracurium) Ref: Clinical Anaesthesia 3rd edn, Morgan 191; KDT 4th edn, 154; Lee 12th, 213; SARP-SARP 6th edn, 122; PARAS-PARAS 4th edn, 58; Sure Sucess in PG Entrance 1st edn, 102 Quality: Spotter Status: Repeat QTDF: All books (except Tripathi) give this. Tripathi says vecuronium !!! Discussion Balanced Anaesthesia (introduced by Lundy) is: 1. Thiopentone for induction 2. N2O for Amnesia 3. Opiod for Analgesia 4. Curare for Muscle relaxation Atracurium is Benzylisoquinoliniums Undergoes Hoffmans degradation at body temperature Stored at 4oC Relaxant of choice in patients with hepatic or renal dysfunction Suitable for patients with Atypical Cholinesterase, Organophosphorus poisoning and in myasthenia gravis Contraindicated in Asthma Side effect is Histamine release Metabolite is laudanosine which is a CNS Derivative Explanation Do we need an explanation !! 1. Pancuronium.is not used in liver failure 2. Gallamine is totally excreted by kidney 3. Atracurium undergoes Hoffmans degradation 4. Vecuronium is safe in Liver failure and has no Cardiovascular side effects and does not release histamine Comments Atracurium undergoes Hoffman degradation (95%) and also ester hydrolysis (5%) in plasma. Tips Xenobiotics can hurl a question at you in unexpected places. Be prepared !!! 7. During rapid sequence induction of anesthesia: A. Selicks maneuver is not required. B. Pre-oxygenation is mandatory. C. Suxamethonium is contraindicated. D. Patient is mechanically ventilated before end tracheal incubation. 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Structural hemoglobinopathies u occur when mutations alter the amino acid sequence of a globin chain, altering the physiologic properties of the variant hemoglobins and producing the characteristic clinical abnormalities. u The variant hemoglobins relevant to this chapter polymerize abnormally, as in sickle cell anemia, or exhibit altered solubility or oxygen-binding affinity. Thalassemia syndromes arise from mutations that u impair production or translation of globin mRNA, leading to deficient globin chain biosynthesis. u Clinical abnormalities are attributable to the inadequate supply of hemoglobin and the imbalances in the production of individual globin chains, u leading to premature destruction of erythroblasts and red cells. Thalassemic hemoglobin variants combine features of u thalassemia (e.g., abnormal globin biosynthesis) and of u structural hemoglobinopathies (e.g., an abnormal amino acid sequence). Hereditary persistence of fetal hemoglobin (HPFH) is characterized by u synthesis of high levels of fetal hemoglobin in adult life. Acquired hemoglobinopathies include u modifications of the hemoglobin molecule by toxins (e.g., acquired methemoglobinemia) and u abnormal hemoglobin synthesis (e.g., high levels of HbF production in preleukemia and a-thalassemia in myeloproliferative disorders). Few details about HbS HEMATOLOGY Normal in the heterozygote; hemolytic anemia of varying degrees in homozygotes; painful vasoocclusive episodes; leg ulcers; jaundice, stroke, congestive heart failure; meningitis; lowered resistance to salmonella and pneumococcus organisms ELECTROPHORESIS Hb S and Hb A can readily be separated at both alkaline and acidic pH CHROMATOGRAPHY Hb S and Hb A separate by both cation and anion exchange chromatography STRUCTURE STUDIES Tryptic digestion; fingerprinting; cation exchange chromatography; amino acid analysis; sequencing; HPLC DNA ANALYSES A GAG->GTG mutation at codon 6 FUNCTION STUDIES Normal STABILITY Normal; in the deoxy form Hb S precipitates, particularly at higher salt concentrations OCCURRENCE Heterozygotes and homozygotes found in many ethnic groups but predominantly in the Black race and in some Indian tribes OTHER INFORMATION Hb S is the most studied Hb variant; Explanation A. An abnormality in porphyrin part of hemoglobin will lead to Porphyrias. B. Replacement of glutamate by valine in B-chain of HbA is the cause of HbS. C. A nonsense mutation in the B-chain of HbA will lead to chain termination. D. Substitution of valine by glutamate in the alpha chain of HbA will lead Hb Pavie in which Valine in Position 135 is replaced by Glutamate. And The following table gives the Hemoglobin variants caused by the Substitution of valine by glutamate in the beta chain of HbA Hb Position Original AA Replaced AA Original Sequence Mutation Trollhttan 20(B2) Val Glu GTG GAG Cagliari 60(E4) Val Glu GTG GAG M-Milwaukee-I 67(E11) Val Glu (GTG GAG) Mainz 98(FG5) Val Glu (GTG GAG) New York 113(G15) Val Glu GTG GAG Hofu 126(H4) Val Glu GTG GAG North Shore 134(H12) Val Glu (GTG GAG) Comments Since most of the details for this are already in all the books, let us see few facts which are likely to be asked in future exams The types and number of Hemoglobin variants are Type Number Alpha Chain variants 199 Beta Chain variants 335 Gamma Chain variants (G-gamma = 38; A-gamma = 20; unknown = 3; special = 7) 68 Delta Chain variants 28 Variants with two amino acid replacements (alpha = 1; beta = 17) 18 Variants with hybrid chains 10 Variants with elongated chains (at the C-terminus = 9; at the N-terminus = 4) 13 Variants with deletions (15); with insertions (4); with deletions and insertions (3) 22 Total 693 Few Hemoglobins where the substitution occurs in Position 6 in beta Chain Hb Position Original AA Replaced AA Original Sequence Mutation S 6(A3) Glu Val GAG GTG C 6(A3) Glu Lys GAG AAG G-Makassar 6(A3) Glu Ala (GAG GCG) Machida 6(A3) Glu Gln (GAG CAG) One more alpha chain disorder which I Ann Arbor 80(F1) Leu->Arg (CTG->CGG) Tips Refer Table 106 1 in Harrison 15th Edition and the relevant chapters in Nelson Question. 31. Decreased Glycolytic activity impairs oxygen transport by hemoglobin due to: A. Reduced energy production. B. Decreased production of 2,3-bisphosphoglycerate. C. Reduced synthesis of hemoglobin. D. Low levels of oxygen. Answer B. Decreased production of 2,3-bisphosphoglycerate. Ref: Harper 25th,Pages 70, 195 Lippincott 2nd Edition Pages 31,92 Figure 7.8 Textbook of Medical Biochemistry 4th Edition Chaterjee and Shinde Page 258 Quality: Reader Status: Thinker QTDF: Harper Discussion 2,3 DPG (2,3-biphosphoglycerate) is produced by the alternate pathway and when the glycolytic activity decreases, the amount of 2,3DPG decreases and we all know that 2,3-DPG releases oxygen from Hb to the tissues. Thus when there is low amount of 2,3-DPG, there is Shift to left, that is Oxygen is bound tightly to the Hb and as a result there is decreased availability of Oxygen to the tissues Explanation A. Oxygen delivery is not related to energy production . B. Decreased production of 2,3-bisphosphoglycerate leads to shift to left. C. Decreased glycolytic activity does not Reduce synthesis of hemoglobin all of a sudden. D. Low levels of oxygen leads to decreased glycolytic activity (of course) but not the opposite as given in this choice. 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Explanation A. Cytochrome P-450 : the chief enzyme involved in activation of Strangers is monooxygenase or Cytochrome P450 NADPH - cytochrome P 450 Reductase is involved in the reactivation of Cytochrome P -450 which is not a stranger B. Glutathione S-transferase is an enzyme involved in activation of Xenobiotics, Harper has clearly stated that of all Phase 1 reactions it is Hydroxylation (Monooxygenation - Monooxygenatiuon means adding One Oxygen. When that oxygen is added to a R-H group we get R-OH and because of that -OH we call it as hydroxylation) which is important. Hence there is no doubt regarding this enzyme is not the main enzyme C. NADPH cytochrome P-450-reductase.is involved, but not in activation of Xenobiotics : Xenobiotics is (Gk xenos stranger) is a compound that is foreign to the body, the principal classes of Xenobiotics of medical relevance are drugs, chemical carcinogens. Obviously, P 450 is not a Xenobiotic !!!! Then how come an enzyme (which activates another enzyme, which is in our body) be a main enzyme in the activation of Xenobiotics !!!!!Again the question is clear.. ACTIVATION of Xenobiotics. Atleast if the question is concerned with Xenobiotics.. there can be a little confusion D. Glucuronyl transferase . is an enzyme involved in activation of Xenobiotics, but it is not the main enzyme Comments The confusa in this question is due to the line NADPH, not NADH is involved in the reaction mechanism of cytochrome P 450 in Harper. But as explained, NADPH and NADH is used, but not used in the activation of Xenobiotics. Tips Xenobiotics is a High Yield Topic in both Biochemistry and Pharmavology Question. 35. The protein rich in basic amino acids, which functions in the packaging of DNA in chromosomes, is: A. Histone. B. Collagen. C. Hyaluronic acid binding protein. D. Fibrinogen. Answer A. Histone. Ref: Harper 25th Edition Page 412 Quality: Spotter Status: Repeat QTDF: Harper Discussion Histones are Proteins found in the nuclei of all eukaryotic cells where they are complexed to DNA in chromatin and chromosomes. They are of relatively low molecular weight and are basic, having a very high arginine/lysine content. They are highly conserved and can be grouped into five major classes. Two copies of H2A, H2B, H3 and H4 bind to about 200 base pairs of DNA to form the repeating structure of chromatin, the nucleosome, with H1 binding to the linker sequence. They may act as non-specific repressors of gene transcription. Explanation A. Histones . B. Collagen is The protein substance of the white fibres (collagenous fibres) of skin, tendon, bone, cartilage and all other connective tissue, composed of molecules of tropocollagen, it is converted into gelatin by boiling. The word has originated from the Greek word Kolla = glue and gennan = to produce are the structural mole. C. Hyaluronic acid binding protein occurs in Pharyngeal Epithelial cells. The capsular polysaccharide of Group A Streptococcus plays a role in colonization of the pharynx by binding to CD44, a hyaluronic acid-binding protein expressed on human pharyngeal epithelial cells. Though this is not related to this question, I have given this because this may be asked in future. Hyaluronic acid binding protein 2 Is a serine protease D. Fibrinogen is Soluble plasma protein (340 kD, 46 nm long), composed of 6 peptide chains (2 each of A_, B_ and _) and present at about 2-3 mg/ml.. Comments Question from Genetics are asked directly from Harper and are often taken from the Blue Headings given before each Paragraph. Tips If you dont have time to read Harper thoroughly read atleast the Blue Headings given at the top of each paragraph Question. 36. Which of the following is not a post transcriptional modification of RNA? A. Splicing. B. 5' Capping. C. 3' polyadenylation. D. Glycosylation. Answer D. Glycosylation. Ref: Harper 25th Edition Page 448 Lippincott 2nd Edition page 385,386 Quality: Reader Status: Repeat QTDF: Harper Discussion Transciption as we all know is a step in the synthesis of mRNA from DNA. First heteronuclear RNA (hnRNA) is synthesized (which in nothing but a reverse or complimentary copy of the DNA (From which it was synthesized) the sequence of which is exactly same as the other strand of DNA (except for the Uracil), and it undergoes few changes, (which are called as post transcriptional modifications) to become an active mRNA . The changes are Additions u 5 capping Addition of 7 methyl guanosine capping to Initiate translation Protection of 5 end from attack of 5-3 exonuclease u 3 capping Addition of Poly A Tail or 3 polyadenylation Splicing Removal of Introns and Merging the Exons Explanation A. Splicing occurs. lG(xKddd ,(xKddF (xKdd] (xKdd0 (xKddh(xKdddh(xKddd h(xKddd h(xKdddh(xKddd (xKddah<(xKdddX(xKdddX(xKdddX(xKddd(X(xKddd ,(xKdd' ,(xKdd (xKdd) (xKdd (xKdd (xKdd (xKdd (xKdd (xKdd (xKdd (xKdd (xKdd ,(xKdd  (xKdd'(xKddd(xKddd(xKddd(xKddd$(xKddd(xKddd(xKddd% dP(xKdd (xKddd(xKddd&(xKddd(xKddd(xKddd ,(xKdd5X(xKddd1X(xKddd8X(xKdddHX(xKddd ,(xKdd (xKdd ,(xKdd (xKddh<(xKdddX(xKddd X(xKddd X(xKddd X(xKddd ,(xKdd ,(xKdd (xKdd* (xKdd (xKdd (xKdd (xKdd (xKdd (xKdd (xKdd (xKdd (xKdd (xKdd ,(xKdd (xKddlopathy C. Severe hypovolemia. D. Pre-existing neurological deficits. Answer: D (Pre-existing neurological deficits) Ref: Clinical Anaesthesia 3rd edn Morgan 262; Lee 12th edn, 369; PARAS-PARAS 4th edn, 66; Quality: Reader Status: New Question QTDF: Morgan Discussion Neuraxial block means spinal and epidural anesthesia as well as Caudal Blocks and here the agent acts at the level of the Nerve Root. 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Sellick smaneuver is done B. Pre oxygenation is done for 4 to 5 minutes C. Suxamethonium is given D. Mechanical ventilation is not done for the fear of filling up stomach with gas and there by potentiating vomiting Comments A new question in Anaesthesia out of our regular books we follow (SARP etc) Tips Questions like these are proof that solving AIPG and AIIMS question papers require in-depth knowledge of the subjects 8. A 5-year-old boy suffering from Duchenne muscular dystrophy has to undergo tendon-lengthening procedure. The most appropriate anaesthetic would be: A. Induction with intravenous thiopentone and N2O; and halothane for maintenance. B. Induction with intravenous propofol and N2O; and oxygen for maintenance. C. Induction with intravenous suxamethonium and N2O; and halothane for maintenance. D. Inhalation induction with inhalation halothane and N2O; oxygen for maintenance. Answer: B (Induction with intravenous Propofol and N2O; and oxygen for maintenance) Ref: Miller 5th edn, 422; Nelson 15th edn Quality: Thinker Status: Repeat from AIIMS QTDF: Miller Discussion ANAESTHESIA IN A CASE OF NEUROMUSCUALR DISEASE: In neuromuscular diseases, anaesthesia of choice is peripheral nerve blocks, local and central neuraxial block (below T9). If GA is to be given than it should be contemplated with total intravenous anaesthesia (propofol + fentanyl) and maintained on oxygen, nitrous oxide and opioid. Relaxation, if needed ,is achieved by inhalational agents and if sufficient relaxation is not achieved by them non depolarizing relaxants like atracurium should be given and dose is adjusted according to neuromuscular monitoring response. Halothane causes MALIGNANT HYPERPYREXIA and should not be used. Succinyl Choline causes Intractable Cardiac Arrest in a child with Duchenne Muscular Dystrophy Another view is that, for a normal patient, In any surgery involving muscle lengthening / shortening, the dictum is not using Ether / Halothane which can alter the tension of the muscle and use N2O which has no effect on muscles.... Explanation A. Halothane cannot be used B. This is the correct answer C. Both Succinyl Choline as well as Halothane cannot be used and this seems to be a preposterous choice !! D. Halothane cannot be used Comments Malignant Hyperthermia occurs in individuals with an inherited abnormality of skeletal-muscle sarcoplasmic reticulum that causes a rapid increase in intracellular calcium levels in response to halothane and other inhalational anesthetics or to succinylcholine. Elevated temperature, Increased muscle metabolism, Rigidity, Rhabdomyolysis, Acidosis, and Cardiovascular instability develops rapidly. This condition is often fatal. Earliest sign Masseter Muscle Rigidity Other signs Tachycardia, Hybercarbia Triggering Drugs Protective Drugs Enflurane, Isoflurane, Nitrous Oxide Desflurane, Sevoflurane, Droperidol Methoxy Flurane Local Anaesthetics Succinyl Choline Etomidate Pancuronium Propofol Thiopentone Ketamine m To be treated immediately m Cessation of anesthesia and m Intravenous administration of dantrolene sodium. u The recommended dose of dantrolene is 1 to 2.5 mg/kg of body weight given intravenously every 6 h for at least 24 to 48 h-until oral dantrolene can be administered, if needed. u Dantrolene at similar doses is indicated in the 3 Neuroleptic malignant syndrome. 3 In drug-induced hyperthermia and may even be useful in the 3 Hyperthermia of Thyrotoxicosis. m Procainamide should also be administered to patients with malignant hyperthermia because of the likelihood of ventricular fibrillation in this syndrome. The neuroleptic malignant syndrome can occur with phenothiazines and other drugs such as haloperidol and is Characterized by u Muscle rigidity, u Autonomic dysregulation, and u Hyperthermia. This disorder appears to be caused by the u Inhibition of central dopamine receptors in the hypothalamus, u Which results in Increased heat generation and u Decreased heat dissipation. u Thyrotoxicosis and pheochromocytoma can also cause increased thermogenesis. The neuroleptic malignant syndrome may also be treated with u Bromocriptine, u Levodopa, u Amantadine, or u Nifedipine or u By induction of muscle paralysis with curare and pancuronium. u Tricyclic antidepressant overdose may be treated with physostigmine Tips A repeat question from AIIMS. May be you will get this is future too Read the basics about the anaesthesia in certain disease conditions and physiological states Drugs causing Malignant Hyperthermia are SCHEMe Succinyl Choline Cyclopropane Halothane Ether Methoxy Flurane 9. In all of the following conditions neuraxial blockade is absolutely contraindicated, except: A. Patient refusal. B. Coagulopathy C. Severe hypovolemia. D. Pre-existing neurological deficits. Answer: D (Pre-existing neurological deficits) Ref: Clinical Anaesthesia 3rd edn Morgan 262; Lee 12th edn, 369; PARAS-PARAS 4th edn, 66; Quality: Reader Status: New Question QTDF: Morgan Discussion Neuraxial block means spinal and epidural anesthesia as well as Caudal Blocks and here the agent acts at the level of the Nerve Root. There are a few Absolute and Few Relative contraindiations for Spinal and Epidural Anaesthesis. The Absolute contraindications are: 1. Infection at the site of Injection 2. Patient refusal 3. Coagulopathy 4. 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